Evidence map›Paper›PMID 34139523›Full record

ArticleSeminars in arthritis and rheumatism2021

A multidisciplinary assessment of pain in juvenile idiopathic arthritis.

Jaymin Upadhyay, Jordan Lemme, Mariesa Cay, Hanne Van Der Heijden, Diana Sibai, Benjamin Goodlett, Jeffery Lo, Kacie Hoyt, Maria Taylor, Melissa M Hazen and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Seminars in arthritis and rheumatism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address: jaymin.upadhyay@childrens.harvard.edu.
Jordan LemmeDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Hanne Van Der HeijdenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, the Netherlands; Faculty of Science, Biomedical Sciences Neurobiology, University of Amsterdam, Amsterdam, the Netherlands.
Diana SibaiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin GoodlettDivision of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jeffery LoDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kacie HoytDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Maria TaylorDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Melissa M HazenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Olha HalyabarDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Esra MeidanDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rudy SchreiberFaculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, the Netherlands.
Margaret H ChangDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Camilo JaimesDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A HendersonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kirsten EcklundDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Robert P SundelDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USBoston Children's Hospital · USMaastricht University · NL

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
The Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9M
Dissecting Central Mechanisms of Hypoalgesia in SchizophreniaR21MH122967 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SHINN, ANN KYUNGAH, UPADHYAY, JAYMIN A · 2020 to 2020
$490k
NIAID NIH HHS T32 AI007512NIAMS NIH HHS P30 AR070253NICHD NIH HHS K12 HD052896NIMH NIH HHS R21 MH122967
6 · The paper itself

Abstract

introductionPain is prevalent in juvenile idiopathic arthritis (JIA). Unknowns regarding the biological drivers of pain complicate therapeutic targeting. We employed neuroimaging to define pain-related neurobiological features altered in JIA.

methods16 male and female JIA patients (12.7 ± 2.8 years of age) on active treatment were enrolled, together with age- and sex-matched controls. Patients were assessed using physical examination, clinical questionnaires, musculoskeletal MRI, and structural neuroimaging. In addition, functional magnetic resonance imaging (fMRI) data were collected during the resting-state, hand-motor task performance, and cold stimulation of the hand and knee.

resultsPatients with and without pain and with and without inflammation (joint and systemic) were evaluated.  Pain severity was associated with more physical stress and poorer cognitive function. Corrected for multiple comparisons, morphological analysis revealed decreased cortical thickness within the insula cortex and a negative correlation between caudate nucleus volume and pain severity. Functional neuroimaging findings suggested alteration within neurocircuitry structures regulating emotional pain processing (anterior insula) in addition to the default-mode and sensorimotor networks.

conclusionsPatients with JIA may exhibit changes in neurobiological circuits related to pain. These preliminary findings suggest mechanisms by which pain could potentially become dissociated from detectable joint pathology and persist independently of inflammation or treatment status.

Indexed as

Arthritis, JuvenileFemaleHumansKnee JointMagnetic Resonance ImagingMalePainPain MeasurementAnterior insulaCaudateFunctional magnetic resonance imagingInflammationJuvenile idiopathic arthritisMusculoskeletalPainVoxel-based morphometry

Identifiers

PMID34139523
PMCPMC9741862
OpenAlexW3166121926

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.