Evidence map›Paper›PMID 34139278›Full record

ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2021

Individual variation in diurnal cortisol in patients with knee osteoarthritis: Clinical correlates.

Myrella Paschali, Asimina Lazaridou, Theodoros Paschalis, Julia R Moradian, Jason Sadora, Eric S Vilsmark, Robert R Edwards

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.International journal of environmental research and public health · 2023
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Myrella PaschaliDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA. Electronic address: mpaschali@bwh.harvard.edu.
Asimina LazaridouDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA.
Theodoros PaschalisDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA; Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Rd, Cambridge CB2 0QQ, UK.
Julia R MoradianDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA.
Jason SadoraDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA; Fielding Graduate University, 2020 De La Vina St, Santa Barbara, CA 93105, USA.
Eric S VilsmarkDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA.
Robert R EdwardsDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, 850 Boylston St, Suite 302, Chestnut Hill, MA 02467, USA.
Brigham and Women's Hospital · USChestnut Hill College · USFielding Graduate University · US

Funding

Pain in community-based older African American Adults: The Jackson Heart StudyR01AG066914 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2024
$3.2M
Biobehavioral Risk Factors for Persistent Pain following Total Knee ArthroplastyR01AG034982 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2010 to 2014
$3.2M
NIA NIH HHS R01 AG034982NIA NIH HHS R01 AG066914
6 · The paper itself

Abstract

backgroundThe cortisol awakening response (CAR) is a core biomarker of hypothalamic-pituitary-adrenal (HPA) axis regulation. To date, however, studies of HPA-axis function among patients with chronic pain are scarce and show equivocal results. The objectives of this study were to investigate the association between CAR and pain-related outcomes and to investigate potential sex differences in patients with knee osteoarthritis (KOA).

methodsIn this cross-sectional study, KOA patients (N = 96) completed self-report questionnaires assessing pain and psychosocial factors and underwent Quantitative Sensory Testing (QST) to assess pressure pain threshold (PPT). Additionally, salivary cortisol samples (N = 60) were collected to assess HPA-axis function at 6 time points (awakening, 15- and 30-minute post-awakening, 4 PM, 9 PM and bedtime). The CAR was calculated by examining increases in salivary cortisol from awakening to 30 min post awakening and the total post-awakening cortisol concentration by calculating the lower areas under the curve of cortisol with respect to ground (AUC

resultsPatients with a relatively blunted CAR had significantly higher anxiety levels and lower PPT than patients with relatively normal CAR. Similarly, patients with a relatively reduced AUC

Indexed as

HydrocortisoneOsteoarthritis, KneeCircadian RhythmCross-Sectional StudiesFemaleHumansHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemSalivaHydrocortisoneCortisolCortisol awakening responseOsteoarthritisPainPain thresholdSex

Identifiers

PMID34139278
PMCPMC8328951
OpenAlexW3168439570

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.