Evidence map›Paper›PMID 34139183›Full record

ArticleNeuron2021

Questioning the causality of HTT CAG-repeat expansions in FTD/ALS.

Quentin Thomas, Giulia Coarelli, Anna Heinzmann, Isabelle Le Ber, Maria Del Mar Amador, Alexandra Durr

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Repeat expansions inBrain communications · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Quentin ThomasAP-HP, Genetic Department, University Hospital Pitié-Salpêtrière, Paris, France.
Giulia CoarelliAP-HP, Genetic Department, University Hospital Pitié-Salpêtrière, Paris, France; Sorbonne University, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Paris, France.
Anna HeinzmannAP-HP, Genetic Department, University Hospital Pitié-Salpêtrière, Paris, France; Sorbonne University, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Paris, France.
Isabelle Le BerSorbonne University, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Paris, France; AP-HP, National Reference center "rare and young dementias," IM2A, University Hospital Pitié-Salpêtrière, Paris, France.
Maria Del Mar AmadorAP-HP, Genetic Department, University Hospital Pitié-Salpêtrière, Paris, France; Sorbonne University, Department of Neurology, National Reference center ALS Paris, AP-HP, University Hospital Pitié-Salpêtrière, Paris, France.
Alexandra DurrAP-HP, Genetic Department, University Hospital Pitié-Salpêtrière, Paris, France; Sorbonne University, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Paris, France. Electronic address: alexandra.durr@icm-institute.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaDNA Repeat ExpansionHumansHuntingtin ProteinHTT protein, humanHuntingtin Protein

Identifiers

PMID34139183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.