Evidence map›Paper›PMID 34139161›Full record

ReviewCell systems2021

A forecast for large-scale, predictive biology: Lessons from meteorology.

Markus W Covert, Taryn E Gillies, Takamasa Kudo, Eran Agmon

Abstract readReview
In one paragraph

Review in Cell systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Markus W CovertDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA. Electronic address: mcovert@stanford.edu.
Taryn E GilliesDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Takamasa KudoDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Eran AgmonDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Funding

Deep Curation via an Integrated Whole-Cell Computational ModelR01LM013229 · NLM · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2020 to 2023
$1.5M
Adding an environment and motility in a Whole Cell Model of Escherichia ColiF32GM137464 · NIGMS · STANFORD UNIVERSITY · PI AGMON, ERAN · 2020 to 2021
$138k
A model-driven investigation into the role of operon structure and sub-generational expression in Escherichia coliF32GM137528 · NIGMS · STANFORD UNIVERSITY · PI GILLIES, TARYN · 2020 to 2020
$54k
NIGMS NIH HHS F32 GM137464NIGMS NIH HHS F32 GM137528NLM NIH HHS R01 LM013229
6 · The paper itself

Abstract

Quantitative systems biology, in which predictive mathematical models are constructed to guide the design of experiments and predict experimental outcomes, is at an exciting transition point, where the foundational scientific principles are becoming established, but the impact is not yet global. The next steps necessary for mathematical modeling to transform biological research and applications, in the same way it has already transformed other fields, is not completely clear. The purpose of this perspective is to forecast possible answers to this question-what needs to happen next-by drawing on the experience gained in another field, specifically meteorology. We review here a number of lessons learned in weather prediction that are directly relevant to biological systems modeling, and that we believe can enable the same kinds of global impact in our field as atmospheric modeling makes today.

Indexed as

MeteorologyModels, BiologicalModels, TheoreticalSystems Biologycomputational biologysystems biologywhole-cell modeling

Identifiers

PMID34139161
PMCPMC8217727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.