ArticleCell systems2021
A time-resolved proteomic and prognostic map of COVID-19.
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Article in Cell systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
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107citing papers in PubMed, 1 pooled it
12.7field-weighted citation impact, top 1% of its field
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Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 213 citations in OpenAlex.
- Progress and trends on machine learning in proteomics during 1997-2024: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.Nature communications · 2026Article
- 7-day longitudinal proteomics of critically ill patients: a pilot study.Scientific reports · 2026Observational
- Transcriptome graph transformer: a graph transformer-based unsupervised model for transcriptome data analysis.BMC bioinformatics · 2026Article
- Structural promiscuity in the human circulatory IgA1 clonal repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Primary (AL) Amyloidosis Following COVID-19 Infection: A Case Report.Clinical case reports · 2026Article
- Cross-platform clinical proteomics using the Charité open standard for plasma proteomics (OSPP).Nature communications · 2025Article
- Systems Virology at Scale.Current opinion in systems biology · 2025Article
- Rare Structural Variants Uncovered by Optical Genome Mapping in Multisystem Inflammatory Syndrome in Children (MIS-C).Advanced genetics (Hoboken, N.J.) · 2025Article
- Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity.Kidney international reports · 2025Article
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- Plasma Proteomics Reveals Distinct Signatures in Occult and Microfilaremic Loa loa Infections.The Journal of infectious diseases · 2025Article
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- Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes.Scientific reports · 2025Article
- Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19.Journal of medical virology · 2025Article
- Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments.iScience · 2025Article
- 4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection.Journal of proteome research · 2025Article
- Exploration of the plasma proteomic profile of patients at risk of thromboembolic events.Research and practice in thrombosis and haemostasis · 2025Article
- A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research.Communications biology · 2025Article
- Dynamic Cellular Proteome Remodeling during SARS-CoV-2 Infection. Identification of Plasma Protein Readouts.Journal of proteome research · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
64 authors at 12 institutions in 5 countries.
Vadim DemichevCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; The University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge CB21GA, UK.
Pinkus Tober-LauCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Oliver LemkeCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Tatiana NazarenkoUniversity College London, Department of Mathematics, London WC1E 6BT, UK; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK.
Charlotte ThibeaultCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Harry WhitwellNational Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW72AZ, UK; Lobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; Imperial College London, Section of Bioanalytical Chemistry, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, London SW7 2AZ, UK.
Annika RöhlCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Anja FreiwaldCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Lukasz SzyrwielThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Daniela LudwigCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Clara Correia-MeloThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Simran Kaur AulakhThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Elisa T HelbigCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Paula StubbemannCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Lena J LippertCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Nana-Maria GrüningCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany.
Oleg BlyussLobachevsky University, Department of Applied Mathematics, Nizhny Novgorod 603105, Russia; University of Hertfordshire, School of Physics, Astronomy and Mathematics, Hatfield AL10 9AB, UK; Sechenov First Moscow State Medical University, Department of Paediatrics and Paediatric Infectious Diseases, Moscow 119435, Russia.
Spyros VernardisThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Matthew WhiteThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Christoph B MessnerCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK.
Michael JoannidisMedical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
Thomas SonnweberMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Sebastian J KleinMedical University Innsbruck, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, 6020 Innsbruck, Austria.
Alex PizziniMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Yvonne WohlfarterMedical University of Innsbruck, Institute of Human Genetics, 6020 Innsbruck, Austria.
Sabina SahanicMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Richard HilbeMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Benedikt SchaeferMedical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Sonja WagnerMedical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Mirja MittermaierCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
Felix MachleidtCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Carmen GarciaCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Christoph Ruwwe-GlösenkampCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Tilman LingscheidCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Laure Bosquillon de JarcyCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Miriam S StegemannCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Moritz PfeifferCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Linda JürgensCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Sophy DenkerCharité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology & Tumor Immunology, Virchow Campus & Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany.
Daniel ZicklerCharité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
Philipp EnghardCharité Universitätsmedizin Berlin, Department of Nephrology and Internal Intensive Care Medicine, 10117 Berlin, Germany.
Aleksej ZelezniakThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK; Chalmers Tekniska Högskola, Department of Biology and Biological Engineering, SE-412 96 Gothenburg, Sweden.
Archie CampbellUniversity of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
Caroline HaywardUniversity of Edinburgh, MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
David J PorteousUniversity of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK; University of Edinburgh, Usher Institute, Edinburgh EH16 4UX, UK.
Riccardo E MarioniUniversity of Edinburgh, Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Edinburgh EH4 2XU, UK.
Alexander UhrigCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Holger Müller-RedetzkyCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany.
Heinz ZollerMedical University of Innsbruck, Christian Doppler Laboratory for Iron and Phosphate Biology, Department of Internal Medicine I, 6020 Innsbruck, Austria.
Judith Löffler-RaggMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
Markus A KellerMedical University of Innsbruck, Institute of Human Genetics, 6020 Innsbruck, Austria.
Ivan TancevskiMedical University of Innsbruck, Department of Internal Medicine II, 6020 Innsbruck, Austria.
John F TimmsUniversity College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK.
Alexey ZaikinUniversity College London, Department of Mathematics, London WC1E 6BT, UK; University College London, Department of Women's Cancer, EGA Institute for Women'S Health, London WC1E 6BT, UK; Lobachevsky University, Laboratory of Systems Medicine of Healthy Ageing, Nizhny Novgorod 603105, Russia.
Stefan HippenstielCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Michael RamharterBernhard Nocht Institute for Tropical Medicine, Department of Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Department of Medicine, 20359 Hamburg, Germany.
Martin WitzenrathCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Norbert SuttorpCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
Kathryn LilleyThe University of Cambridge, Department of Biochemistry and Cambridge Centre for Proteomics, Cambridge CB21GA, UK.
Michael MüllederCharité - Universitätsmedizin Berlin, Core Facility - High-Throughput Mass Spectrometry, 10117 Berlin, Germany.
Leif Erik SanderCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; German Centre for Lung Research, 35392 Gießen, Germany.
PA-COVID-19 Study group
Markus RalserCharité Universitätsmedizin Berlin, Department of Biochemistry, 10117 Berlin, Germany; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK. Electronic address: markus.ralser@charite.de.
Florian KurthCharité Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Department of Medicine, 20359 Hamburg, Germany.
Charité - Universitätsmedizin Berlin · DEInnsbruck Medical University · ATThe Francis Crick Institute · GBUniversity of Cambridge · GBEdinburgh Cancer Research · GBLondon Women's Clinic · GBUniversität Hamburg · DEUniversität Innsbruck · ATBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEInstitute of Genetics and Cancer · GBImperial College London · GBUniversity of Hertfordshire · GB
Funding
Medical Research Council MC_UU_00007/10Medical Research Council MR/R02524X/1Wellcome Trust FC001134
Abstract
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease.
Indexed as
Disease ProgressionAge FactorsBiomarkersBlood Cell CountBlood Gas AnalysisCOVID-19Enzyme ActivationHumansInflammationMachine LearningPrognosisProteomeProteomicsSARS-CoV-2BiomarkersProteomebiomarkersclinical disease progressionCOVID-19disease prognosislongitudinal profilingmachine learningpatient trajectoriesphysiological parametersproteomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.