Evidence map›Paper›PMID 34139039›Full record

ArticleGlia2021

Elovl5 is required for proper action potential conduction along peripheral myelinated fibers.

Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora DiGregorio and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Glia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Eriola HoxhaNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.ORCID 0000-0002-4452-889X
Ilaria BalboNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Roberta ParolisiNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Matteo AudanoDepartment. of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Francesca MontaroloNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Francesco RaveraNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.ORCID 0000-0003-4452-2591
Michela GuglielmottoNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Luisa MuratoriNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Stefania RaimondoNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Eleonora DiGregorioMedical Genetics Unit, Città della Salute e della Scienza Hospital and Dept. of Medical Sciences, University of Torino, Torino, Italy.
Annalisa BuffoNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
Alfredo BruscoMedical Genetics Unit, Città della Salute e della Scienza Hospital and Dept. of Medical Sciences, University of Torino, Torino, Italy.
Barbara BorroniCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Nico MitroDepartment. of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Donatella CarusoDepartment. of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Filippo TempiaNeuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
5T Torino (Italy) · ITNeuroscience Institute · ITUniversity of Milan · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation with other enzymes guarantees the normal levels of very long-chain fatty acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity of myelin, which is maintained by a correct amount of fatty acids and a proper interaction between fatty acids and myelin proteins. We hypothesized that in Elovl5

Indexed as

AxonsMyelin SheathAction PotentialsAnimalsFatty Acid ElongasesFatty AcidsMiceNeural ConductionPeripheral NervesElovl5 protein, mouseFatty Acid ElongasesFatty Acidsaction potentialaxonElovl5myelinpolyunsaturated fatty acids

Identifiers

PMID34139039
PMCPMC8453547
OpenAlexW3171512388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.