SynthesisTropical medicine & international health : TM & IH2021
Systematic review and meta-analysis of integrated studies on antimicrobial resistance genes in Africa-A One Health perspective.
Synthesis in Tropical medicine & international health : TM & IH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Global spread and antimicrobial resistance of Aeromonas hydrophila in aquatic food animals: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Systematic review and meta-analysis of integrated studies on antimicrobial resistance genes in Africa-A One Health perspective.Tropical medicine & international health : TM & IH · 2021Pooled it
- Pooled it
- The Efficacy of Plant Extracts Against Key Food-Borne Pathogens: A Mechanistic, Applications, and Advances.Microorganisms · 2026Review
- Versatile and portable Cas12a-mediated detection of antibiotic resistance markers.Scientific reports · 2026Article
- Detection and antibiotic resistance of Pasteurella, Salmonella, and yersinia from Guinea pig (Cavia Porcellus) production smallholders in Colombia.Veterinary research communications · 2026Article
- Fecal carriage and molecular characterization of ESBL-producing Enterobacteriaceae among farmers in Mid-Western Uganda.Scientific reports · 2026Article
- Mobilome-driven antimicrobial resistance in a one health context: evidence and lessons from Africa.Frontiers in veterinary science · 2026Review
- Bridging the bioinformatics gap: tool selection for decentralized AMR genomic surveillance in Africa.Frontiers in public health · 2026Article
- Phenotypic resistance and virulence gene profiles of non-typhoidalVeterinary world · 2025Article
- Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project.JMIR research protocols · 2025Article
- Molecular characterization of multidrug-resistant Escherichia coli in the Greater Accra Region, Ghana: a 'One Health' approach.One health outlook · 2025Article
- A Systematic Review and Meta-Analysis on the Presence ofMicroorganisms · 2025Review
- One Health Field Approach Applied to Leptospirosis: A Systematic Review and Meta-Analysis Across Humans, Animals and the Environment.Open forum infectious diseases · 2025Article
- Synergizing Ecotoxicology and Microbiome Data Is Key for Developing Global Indicators of Environmental Antimicrobial Resistance.Microbial ecology · 2024Review
- The importance of "one health approach" to the AMR study and surveillance in Angola and other African countries.One health (Amsterdam, Netherlands) · 2024Review
- Social and ecological determinants of antimicrobial resistance in Africa: a systematic review of epidemiological evidence.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Review
- Investigating the evolution and predicting the future outlook of antimicrobial resistance in sub-saharan Africa using phenotypic data for Klebsiella pneumoniae: a 12-year analysis.BMC microbiology · 2023Article
- A systematic review and meta-analysis on prevalence and antimicrobial resistance profile ofHeliyon · 2023Review
- Extended-spectrum beta-lactamase inOne health (Amsterdam, Netherlands) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing antimicrobial resistance (AMR) raises serious health and financial concerns. However, the main drivers of the emergence, spread and subsequent colonisation of resistant bacterial strains between humans, animals and the environment are still poorly understood.
objectiveThe aim of this review was to identify molecular studies on AMR in One Health settings in Africa and to determine the prevalence of antimicrobial resistance genes in humans, animals and the environment. Due to the very low number of studies including environmental samples, the meta-analysis only includes data obtained from animals and humans.
methodsThe PubMed, Web of Science and Scopus databases were searched, identifying 10 464 publications on AMR in Africa from January 1st, 2000 until June 1st, 2020. Inclusion criteria were: (i) Integrated studies assessing AMR simultaneously in an animal-human, animal-environment, human-environment or animal-human-environment context, (ii) Genotypic characterisation of AMR and (iii) temporal and spatial relationship between samples from humans and animals. Statistical random-effects model meta-analysis was performed.
resultsOverall, 18 studies met our eligibility criteria and were included in this review. Six studies investigated Escherichia coli and Salmonella spp. (N = 6). The most prevalent AMR genes in animals included sul1 (36.2%), sul2 (32.0%), tetA (31.5%), strB (30.8%) and blaTEM (30.0%), whereas sul2 (42.4%), tetA (42.0%), strB (34.9%), blaTEM (28.8%) and sul1 (27.8%) were most prevalent in humans. We observed no clear pattern for a higher prevalence in either the animal or the human reservoir.
conclusionTo date, data on AMR in a One Health perspective in Africa are scarce. Prospective and longitudinal studies using an integrated One Health approach assessing the environment, animals and humans at the same time are needed to better understand the main drivers of AMR sharing in Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.