Evidence map›Paper›PMID 34138864›Full record

ArticlePloS one2021

Comparison of dual-energy computer tomography and dynamic contrast-enhanced MRI for evaluating lung perfusion defects in chronic thromboembolic pulmonary hypertension.

Tawfik Moher Alsady, Till F Kaireit, Lea Behrendt, Hinrich B Winther, Karen M Olsson, Frank Wacker, Marius M Hoeper, Serghei Cebotari, Jens Vogel-Claussen

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Imaging in chronic thromboembolic pulmonary disease: Current practice and advances.International journal of cardiology. Congenital heart disease · 2024
    Review
  4. Review
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  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tawfik Moher AlsadyInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.ORCID 0000-0002-0779-0688
Till F KaireitInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.ORCID 0000-0003-4007-4904
Lea BehrendtInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Hinrich B WintherInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Karen M OlssonBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Lower Saxony, Germany.
Frank WackerInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Marius M HoeperBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Lower Saxony, Germany.
Serghei CebotariDepartment of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, Hannover, Lower Saxony, Germany.
Jens Vogel-ClaussenInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the agreement in detecting pulmonary perfusion defects in patients with chronic thromboembolic pulmonary hypertension using dual-energy CT and dynamic contrast-enhanced MRI. Second, to compare both imaging modalities in monitoring lung perfusion changes in these patients after undergoing pulmonary endarterectomy.

methods20 patients were examined with CT and MRI before and/or after pulmonary endarterectomy. Estimated perfusion defect percentage from both modalities was compared in a lobe-based analysis. Spatial agreement of perfusion defect maps was also assessed.

resultsA significant correlation between CT and MRI based perfusion defect percentage was calculated in all lung lobes (r > 0.78; p < 0.001). In addition, a good spatial agreement between perfusion defect maps was found (mean spatial overlap for the whole lung was 68.2%; SD = 6.9). Both CT and MRI detected improvements in pulmonary perfusion after pulmonary endarterectomy: 8% and 7% decrease in whole lung perfusion defect percentage (p = 0.007 and 0.004), respectively. In a lobe-wise analysis, improvements were statistically significant only in lower lobes using both modalities (reduction in defect percentage ranged from 16-29%; p < 0.02).

conclusionsDual-energy CT is an alternative to MRI in monitoring chronic thromboembolic pulmonary hypertension. Both imaging modalities provided comparable estimations of perfusion defects and could detect similar improvement in lung perfusion after pulmonary endarterectomy.

Indexed as

Contrast MediaHypertension, PulmonaryLungMagnetic Resonance ImagingPulmonary EmbolismTomography, X-Ray ComputedAdultAgedChronic DiseaseEndarterectomyFemaleHumansMaleMiddle AgedContrast Media

Identifiers

PMID34138864
PMCPMC8211171
OpenAlexW3169003085

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.