Evidence map›Paper›PMID 34138450›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022

Screening for symptoms of anxiety and depression in patients treated with renal replacement therapy: utility of the Edmonton Symptom Assessment System-Revised.

Evan Tang, Sumaya Dano, Nathaniel Edwards, Sara Macanovic, Heather Ford, Susan Bartlett, Doris Howell, Madeline Li, Marta Novak, Istvan Mucsi

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06396702 (Emotion And Symptom-focused Engagement), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06396702 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Emotion And Symptom-focused Engagement (EASE) Intervention for the Management of Emotional and Physical Symptoms Among Solid Organ Transplant Recipients-pilot Study

TypeinterventionalSponsorUniversity Health Network, TorontoRan2024 to 2027Enrolled120ConditionsTransplant, Failure,Kidney, Transplant, Failure, HeartArmsEASE-SOT
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Kidney Transplantation Improves Health-Related Quality of Life in Older Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Evan Tang *Multi-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada.
Sumaya Dano *Multi-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada.
Nathaniel EdwardsMulti-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada.
Sara MacanovicMulti-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada.
Heather FordMulti-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada.
Susan BartlettDepartment of Medicine Centre for Outcomes Research and Evaluation, McGill University, Montreal, QC, Canada.
Doris HowellPrincess Margaret Cancer Center and Faculty of Nursing, University of Toronto, Toronto, ON, Canada.
Madeline LiPsychosocial Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Marta NovakUniversity Health Network and Department of Psychiatry, Centre for Mental Health, University of Toronto, Toronto, ON, Canada.
Istvan MucsiMulti-Organ Transplant Program and Division of Nephrology, University Health Network, University of Toronto, 585 University Avenue, Peter Munk Building, Floor 11 Room 188, Toronto, ON, M5G 2N2, Canada. Istvan.mucsi@uhn.ca.ORCID http://orcid.org/0000-0002-4781-4699
University Health Network · CACentre for Advancing Health Outcomes · CAPrincess Margaret Cancer Centre · CAUniversity of Toronto · CA

Funding

CIHR PJT 165915Kidney Foundation of Canada KFOC190008
6 · The paper itself

Abstract

purposeThe Edmonton Symptom Assessment System-revised (ESASr) is widely used in clinical oncology to screen for physical and emotional symptoms. The performance of the anxiety and depression items (ESASr-A and ESASr-D, respectively) as screening tools have not been evaluated in patients treated with renal replacement therapy.

methodsKidney transplant recipients and patients on dialysis were recruited in Toronto. Patients were classified as having moderate/severe depression and anxiety symptoms using the established cut-off score of ≥ 10 on the Patient Health Questionnaire-9 (PHQ-9) and the General Anxiety Disorder-7 (GAD-7) questionnaires.

resultsThis study included 931 participants; 62% male, mean age (SD) 55(16), and 52% White. All participants completed ESASr, however only 748 participants completed PHQ-9 and 769 participants completed GAD-7. Correlation between ESASr item scores and legacy scores were moderately strong (ESASr-D/PHQ-9: 0.61; ESASr-A/GAD-7: 0.64). We found good discrimination for moderate/severe depression and anxiety [area under the receiver operating characteristics curve (95% CI) ESASr-D 0.82(0.78-0.86); ESASr-A 0.87 (0.82, 0.92)]. The cut-off ≥ 2 for ESASr-D [Sensitivity = 0.76; Specificity = 0.77; Likelihood Ratio (LR) + = 3.29; LR - = 0.31] and ≥ 4 for ESASr-A (Sensitivity = 0.75; Specificity = 0.87; LR + = 5.76; LR - = 0.29) had the best combination of measurement characteristics.

conclusionThe identified ESASr-D and ESASr-A cut-off scores may be used to rule out patients without emotional distress with few false negatives. However, the low sensitivity identified in our analysis suggests that neither ESASr-D or ESASr-A are acceptable as standalone screening tools.

Indexed as

DepressionQuality of LifeAnxietyAnxiety DisordersFemaleHumansMaleRenal DialysisSurveys and QuestionnairesSymptom AssessmentAnxietyChronic kidney diseaseClinical utilityDepressionEdmonton Symptom Assessment Survey-RevisedScreening

Identifiers

PMID34138450
OpenAlexW3170685169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.