Evidence map›Paper›PMID 34138446›Full record

Observational studyNeurotoxicity research2021

Dynamic Neutrophil-Lymphocyte Ratios Predict Short-term Prognostic Outcome of Thrombolysis in Patients with Acute Ischemic Stroke.

Yiyun Weng, Jingyu Hu, Junli Ren, Honghao Huang, Chenguang Yang, Jiamin Shen, Wenjing Pan, Fangyue Sun, Haojie Qiu, Yufan Gao and 3 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiyun WengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jingyu HuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Junli RenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Honghao HuangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Chenguang YangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Jiamin ShenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Wenjing PanDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Fangyue SunDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Haojie QiuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Yufan GaoDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Shengqi LiDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China.
Xuerong HuangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China. xuerong_huang@163.com.
Guangyong ChenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, Wenzhou, China. gychen6@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe main purpose of this study was to investigate the dynamic changes of neutrophils-lymphocytes ratios (NLRs) in patients with acute ischemic stroke (AIS) and their relationships with 3-month prognostic outcomes.

methodsTwo hundred ninety-one patients with AIS were included in this study, followed up for 3 months. At admission, 1 and 7 days after recombinant tissue plasminogen activator (r-tPA) injection, blood samples were obtained. Outcome events included excellent outcome, good outcome, and death defined as modified Rankin Scale (mRS) scores of 0-1, 0-2, and 6 respectively.

resultsNLRs measured in admission and 7 days after r-tPA treatment were associated with prognosis outcome after 3 months. Twenty-four-hour NLR is an excellent indicator in forecasting (excellent outcome's the areas under the curve (AUC) = 0.725; good outcome AUC = 0.742; death AUC = 0.759). In addition, we were surprised to find that dynamic increase in NLR within 24 h is significantly related to excellent and good outcomes.

conclusionsTwenty-four-hour NLR is related to the severity of AIS and poor prognosis, which can help early risk stratification. SIGNIFICANCE: We can predict the prognosis of AIS more accurately. Compared with previous studies, our study has shown the dynamic changes of NLR and its relationship with NIHSS and multiple prognostic.

Indexed as

AgedBrain IschemiaFemaleFibrinolytic AgentsFollow-Up StudiesHumansIschemic StrokeLymphocytesMaleMiddle AgedNeutrophilsPredictive Value of TestsPrognosisThrombolytic TherapyTime FactorsTreatment OutcomeFibrinolytic AgentsLymphocytesNeutrophilsNLRPrognosisThrombolysis

Identifiers

PMID34138446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.