Evidence map›Paper›PMID 34138184›Full record

ReviewNano-micro letters2020

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics.

Xin Pang, Dengfeng Li, Jing Zhu, Jingliang Cheng, Gang Liu

Open access · diamondAbstract readReview
In one paragraph

Review in Nano-micro letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 179 citations in OpenAlex.

  1. Review
  2. Article
  3. Sequential HAngewandte Chemie (International ed. in English) · 2026
    Article
  4. HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ultrasound- and NIR-Responsive Polydextran/Black TiOACS applied materials & interfaces · 2025
    Article
  15. Article
  16. Article
  17. pH-Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy.Angewandte Chemie (International ed. in English) · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xin PangHenan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, People's Republic of China. pangxin116@163.com.
Dengfeng LiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, Xiamen, People's Republic of China.
Jing ZhuHenan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, People's Republic of China.
Jingliang ChengHenan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, People's Republic of China. cjr.chli@vip.163.com.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, Xiamen, People's Republic of China. gangliu.cmitm@xmu.edu.cn.
First Affiliated Hospital of Zhengzhou University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.

Indexed as

Multidrug resistantPhotodynamic therapyReactive oxygen speciesSonodynamic therapyTheranostics

Identifiers

PMID34138184
PMCPMC7770670
OpenAlexW3042152090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.