Evidence map›Paper›PMID 34137945›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Head-to-head intra-individual comparison of biodistribution and tumor uptake of

Frederik L Giesel, Clemens Kratochwil, Joel Schlittenhardt, Katharina Dendl, Matthias Eiber, Fabian Staudinger, Lukas Kessler, Wolfgang P Fendler, Thomas Lindner, Stefan A Koerber and 9 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05687747 (Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma), which is not on this map. Cited by 136 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 8 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05687747 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma

TypeinterventionalSponsorNational University Hospital, SingaporeRan2023 to 2026Enrolled100ConditionsHepatocellular CarcinomaArmsRadiolabelled tracer, 68Gallium-FAPI-46 PET/MRI
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 8 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. Head-to-head comparative study of [Frontiers in oncology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. A systematic review of [Frontiers in oncology · 2022
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Same-day dual-tracer PET/CT imaging with [Annals of nuclear medicine · 2025
    Trial
  10. Head-to-head comparison ofAnnals of nuclear medicine · 2025
    Trial
  11. Non-specific uptake ofScientific reports · 2024
    Trial
  12. Head-to-Head Comparison of [Molecular imaging and biology · 2022
    Trial
  13. The Role ofMolecular imaging and radionuclide therapy · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. European journal of nuclear medicine and molecular imaging · 2026
    Article
  19. Review
  20. Advances in radiation oncology · 2026
    Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Frederik L GieselDepartment of Nuclear Medicine, University Hospital Duesseldorf, Duesseldorf, Germany. frederik@egiesel.com.
Clemens KratochwilDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Joel SchlittenhardtDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Katharina DendlDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Matthias EiberDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Fabian StaudingerDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Lukas KesslerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Wolfgang P FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany.
Thomas LindnerDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Stefan A KoerberNational Center for Tumor diseases (NCT), Heidelberg, Germany.
Jens CardinaleDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
David SennungAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, USA.
Manuel RoehrichDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Juergen DebusNational Center for Tumor diseases (NCT), Heidelberg, Germany.
Mike SathekgeDepartment of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.
Jeremie CalaisAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA, USA.
Sebastian SerflingDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Andreas L BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
University Hospital Heidelberg · DEHeidelberg University · DEUniversitätsklinikum Würzburg · DEUniversity of Duisburg-Essen · DEHeinrich Heine University Düsseldorf · DEKlinikum rechts der Isar · DEMolecular Theranostics (United States) · USNational Center for Tumor Diseases · DEUniversity of California, Los Angeles · USUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The purpose of this study is the head-to-head intra-individual comparison of MATERIAL AND

methodsThis international retrospective multicenter analysis included PET/CT data from 71 patients from 6 centers who underwent both

resultsA total of 71 patients were studied of, which 28 were female and 43 male (median age 60). In 41 of 71 patients, the primary tumor was present. Forty-three of 71 patients exhibited 162 metastatic lesions.

conclusionQuantitative tumor uptake is comparable between

Indexed as

NeoplasmsPositron Emission Tomography Computed TomographyFemaleFluorodeoxyglucose F18Gallium RadioisotopesHumansMaleMiddle AgedRetrospective StudiesTissue DistributionFluorodeoxyglucose F18Gallium RadioisotopesCancer-associated fibroblastFAPI PET/CTFDG PET/CTVarious cancer diseases

Identifiers

PMID34137945
PMCPMC8566651
OpenAlexW3167710775

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.