ArticleThe Journal of clinical endocrinology and metabolism2021
Superficial vs Deep Subcutaneous Adipose Tissue: Sex-Specific Associations With Hepatic Steatosis and Metabolic Traits.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-analysis of Sex Differences in Subcutaneous and Visceral Abdominal Fat in Children.Nutrition reviews · 2026Pooled it
- Adipose Tissue Heterogeneity: Depot-Specific Location and Functional Specialization in Obesity-Related Disease.International journal of molecular sciences · 2026Review
- Abdominal fat distribution phenotypes and metabolic risk in premenopausal Asian women: insights beyond general adiposity measures.Scientific reports · 2026Article
- Ultrasound and MRI abdominal fat distribution and its associations with metabolic conditions in adults with abdominal obesity.Diabetes, obesity & metabolism · 2026Article
- Ultrasound-assessed abdominal fat distribution and its relation to sarcopenia parameters in community-dwelling young older adults: a cross-sectional study.Frontiers in endocrinology · 2026Observational
- Crosstalk Between Skeletal Muscle and Proximal Connective Tissues in Lipid Dysregulation in Obesity and Type 2 Diabetes.Metabolites · 2025Review
- The association between new insulin resistance indices and all-cause mortality in elderly patients with diabetes: a prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- The association between the cardiac metabolic index and rapid kidney function decline and CKD in individuals with different glucose metabolism statuses: results from the China health and retirement longitudinal study.Lipids in health and disease · 2025Article
- Association among measurements obtained using portable ultrasonography with sex, body mass index, and age in a large sample of adult population.Journal of translational medicine · 2025Article
- Analysis of Physiological Oxygen Concentrations in Different Abdominal Fat Layers by Body Mass Index.Aesthetic plastic surgery · 2025Article
- Association between cardiometabolic index and albuminuria: Evidence from NHANES 2017-2020.PloS one · 2025Article
- Article
- Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.International journal of obesity (2005) · 2024Observational
- Shrinking fat, healing liver: unlocking the metabolic dysfunction associated steatohepatitis puzzle.Hepatobiliary surgery and nutrition · 2024Article
- Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity.The Journal of clinical endocrinology and metabolism · 2023Article
- Analysis of Superficial Subcutaneous Fat Camper's and Scarpa's Fascia in a United States Cohort.Journal of cardiovascular development and disease · 2023Article
- Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study.Diabetologia · 2023Article
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10 authors.
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Abstract
contextSubcutaneous adipose tissue (SAT) is not homogeneous, as the fascia scarpa separates the deep SAT (dSAT) from the superficial SAT (sSAT).
objectiveThe aim of this study is to evaluate the sex-specific associations of sSAT and dSAT with hepatic steatosis and metabolic syndrome in overweight individuals.
methodsWe recruited 285 individuals with a body mass index (BMI) greater than or equal to 27 and aged 55 to 81 years. Abdominal magnetic resonance imaging was performed around level L4 to L5 to measure visceral adipose tissue (VAT), dSAT, and sSAT volumes. The amount of hepatic fat was quantified by MR spectroscopy.
resultsMen had significantly higher volumes of VAT (122.6 cm3 vs 98.7 cm3, P < .001) and had only half the volume of sSAT compared to women adjusted for BMI (50.3 cm3 in men vs 97.0 cm3 in women, P < .001). dSAT correlated significantly with hepatic fat content in univariate analysis (standardized β = .190, P < .05), while VAT correlated significantly with hepatic steatosis in a multivariate model, adjusted for age, alcohol use, and other abdominal fat compartments (standardized β = .184, P = .037). Moreover, dSAT in men correlated negatively with HDL cholesterol (standardized β = -0.165, P = .038) in multivariate analyses. In women with a BMI between 30 and 40, in a multivariate model adjusted for age, alcohol use, and other abdominal fat compartments, VAT correlated positively (standardized β = -.404, P = .003), and sSAT negatively (standardized β = -.300, P = .04) with hepatic fat content.
conclusionIn men, dSAT is associated with hepatic steatosis and adverse metabolic traits, such as lower HDL cholesterol levels, whereas in women with obesity sSAT shows a beneficial relation with respect to hepatic fat content.
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