ArticleThe Plant cell2021
The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 77 citations in OpenAlex.
- Research Advances in Plant Pyruvate Kinase.International journal of molecular sciences · 2026Review
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- PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance.The Plant journal : for cell and molecular biology · 2026Review
- Multi-Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates.Plant biotechnology journal · 2026Article
- Physiological characteristics and root exudate responses ofFrontiers in plant science · 2026Article
- Physiological and transcriptomic responses of Sargassum hemiphyllum var. chinense to ocean acidification and nitrogen enrichment.BMC genomics · 2025Article
- The metabolite transporters of C4 photosynthesis.The Plant cell · 2025Review
- Genome-Wide Identification and Expression Profiling of Pyruvate Kinase Genes in Litchi Under Calcium-Magnesium Foliar Treatment.Plants (Basel, Switzerland) · 2025Article
- Growth and Physiological Traits of Blueberry Seedlings in Response to Different Nitrogen Forms.Plants (Basel, Switzerland) · 2025Article
- Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications.The Plant journal : for cell and molecular biology · 2025Review
- Multi-Omics Analysis Reveals Differential Molecular Responses of RNA Polymerase Common Subunit ZmRPABC5b for Seedling Development in Maize.Plants (Basel, Switzerland) · 2025Article
- Advances in the Development of Mitochondrial Pyruvate Carrier Inhibitors for Therapeutic Applications.Biomolecules · 2025Review
- Deciphering the Proteome and Phosphoproteome of Peanut (International journal of molecular sciences · 2025Article
- EARLY NODULIN93 acts via cytochrome c oxidase to alter respiratory ATP production and root growth in plants.The Plant cell · 2024Article
- Transcriptome Regulation Mechanisms Difference between Female and MaleInternational journal of molecular sciences · 2024Article
- The Role of Low-Molecular-Weight Organic Acids in Metal Homeostasis in Plants.International journal of molecular sciences · 2024Review
- Comparative transcriptome and coexpression network analysis revealed the regulatory mechanism of Astragalus cicer L. in response to salt stress.BMC plant biology · 2024Article
- Mitochondrial atp1 mRNA knockdown by a custom-designed pentatricopeptide repeat protein alters ATP synthase.Plant physiology · 2024Article
- DIA-Based Quantitative Proteomics in the Flower Buds of TwoInternational journal of molecular sciences · 2024Article
- Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy inFrontiers in plant science · 2024Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Malate oxidation by plant mitochondria enables the generation of both oxaloacetate and pyruvate for tricarboxylic acid (TCA) cycle function, potentially eliminating the need for pyruvate transport into mitochondria in plants. Here, we show that the absence of the mitochondrial pyruvate carrier 1 (MPC1) causes the co-commitment loss of its putative orthologs, MPC3/MPC4, and eliminates pyruvate transport into Arabidopsis thaliana mitochondria, proving it is essential for MPC complex function. While the loss of either MPC or mitochondrial pyruvate-generating NAD-malic enzyme (NAD-ME) did not cause vegetative phenotypes, the lack of both reduced plant growth and caused an increase in cellular pyruvate levels, indicating a block in respiratory metabolism, and elevated the levels of branched-chain amino acids at night, a sign of alterative substrate provision for respiration. 13C-pyruvate feeding of leaves lacking MPC showed metabolic homeostasis was largely maintained except for alanine and glutamate, indicating that transamination contributes to the restoration of the metabolic network to an operating equilibrium by delivering pyruvate independently of MPC into the matrix. Inhibition of alanine aminotransferases when MPC1 is absent resulted in extremely retarded phenotypes in Arabidopsis, suggesting all pyruvate-supplying enzymes work synergistically to support the TCA cycle for sustained plant growth.
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