Evidence map›Paper›PMID 34137616›Full record

ArticleJournal of medicinal chemistry2021

Development of [

Kerstin Sander, Thibault Gendron, Klaudia A Cybulska, Fatih Sirindil, Junhua Zhou, Tammy L Kalber, Mark F Lythgoe, Tom R Kurzawinski, Morris J Brown, Bryan Williams and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Primary aldosteronism.Nature reviews. Disease primers · 2026
    Review
  4. Review
  5. Article
  6. Approach to the Patient With Primary Aldosteronism: Role of Molecular Imaging.The Journal of clinical endocrinology and metabolism · 2025
    Review
  7. Adrenal Vein Sampling in Primary Aldosteronism-Is The Gold Standard Losing Its Luster?The Journal of clinical endocrinology and metabolism · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Primary aldosteronism - a multidimensional syndrome.Nature reviews. Endocrinology · 2022
    Review
  16. Review
  17. Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism.Endocrinology and metabolism (Seoul, Korea) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kerstin SanderCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London WC1E 6BS, U.K.ORCID 0000-0002-6096-7577
Thibault GendronCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London WC1E 6BS, U.K.
Klaudia A CybulskaCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London WC1E 6BS, U.K.
Fatih SirindilCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London WC1E 6BS, U.K.
Junhua ZhouWilliam Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K.
Tammy L KalberCentre for Advanced Biomedical Imaging, University College London, 72 Huntley Street, London WC1E 6DD, U.K.
Mark F LythgoeCentre for Advanced Biomedical Imaging, University College London, 72 Huntley Street, London WC1E 6DD, U.K.
Tom R KurzawinskiNIHR University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, London W1T 7DN, U.K.
Morris J BrownWilliam Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K.
Bryan WilliamsNIHR University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, London W1T 7DN, U.K.
Erik ÅrstadCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London WC1E 6BS, U.K.ORCID 0000-0002-3240-2106
University College London · GBUCL Biomedical Research Centre · GBWilliam Harvey Research Institute · GB

Funding

Medical Research Council MR/T005769/1Wellcome TrustWellcome Trust 102407/Z/13/Z
6 · The paper itself

Abstract

The purpose of this study was to synthesize a fluorine-18 labeled, highly selective aldosterone synthase (

Indexed as

Drug DevelopmentPositron-Emission TomographyAnimalsCytochrome P-450 CYP11B2Cytochrome P-450 Enzyme InhibitorsDose-Response Relationship, DrugFemaleFluorine RadioisotopesHumansHyperaldosteronismMiceMice, Inbred BALB CMolecular StructureStructure-Activity RelationshipCytochrome P-450 CYP11B2Cytochrome P-450 Enzyme InhibitorsFluorine-18Fluorine Radioisotopes

Identifiers

PMID34137616
PMCPMC8273890
OpenAlexW3171523991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.