Evidence map›Paper›PMID 34137504›Full record

ArticleJournal of diabetes investigation2021

Sex-specific differences in blood lipids and lipid ratios in type 2 diabetic foot patients.

Shuming Yin, Puqing Zhao, Zisheng Ai, Bing Deng, Wei Jia, Huan Wang, Jiaqi Zheng

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Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuming YinDivision of Gastroenterology, Department of Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Puqing ZhaoDivision of Respiration, Department of Medicine, Shanghai Traditional Chinese Medicine Integrated Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai, China.
Zisheng AiDepartment of Medical Statistics, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-6264-0965
Bing DengDivision of Cardiology, Department of Medicine, Longhua Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai, China.
Wei JiaDivision of Respiration, Department of Medicine, Shanghai Traditional Chinese Medicine Integrated Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai, China.
Huan WangDepartment of Medical Statistics, School of Medicine, Tongji University, Shanghai, China.
Jiaqi ZhengDepartment of Medical Statistics, School of Medicine, Tongji University, Shanghai, China.

Funding

Key Undergraduate Course Project of Shanghai Education Commission 201965-2National Natural Science Foundation of China 81872718Shanghai Municipal Health and Family Planning Commission 201840041The Outstanding Clinical Discipline Project of Shanghai Pudong PWYgy2018-10
6 · The paper itself

Abstract

AIMS/

introductionFew people have reported whether there are sex differences in blood lipids and lipid ratios in type 2 diabetic foot (T2DF) patients in China. This study attempts to identify the contribution to sex-specific differences in blood lipids and lipid ratios in these patients. MATERIALS AND

methodsIn this case-control study, we explore 306 patients with T2DF as the study group and 306 patients with type 2 diabetes mellitus as the control group. Patients were diagnosed according to the Standards of Medical Care in Diabetes-2014 (American Diabetes Association). Blood lipid and lipid ratios were determined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.

resultsWe studied male patients with T2DF who were aged 68.00 years (18.00 years) and females who were aged 73.50 years (19.00 years); 61.76% of the patients were men. Men had higher body mass index and glycated hemoglobin levels than women. Compared with type 2 diabetes mellitus patients, T2DF patients had significant differences in total cholesterol/high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol/HDL-C and apolipoprotein (apo)B/apoA-I ratios. HDL-C, triglyceride, apoA-I and apoB/apoA-I ratio showed cardiovascular disease risk in men, whereas total cholesterol, low-density lipoprotein cholesterol, apoB, and the low-density lipoprotein cholesterol/HDL-C and total cholesterol/HDL-C ratios were better predictors in women. The apoB/apoA-I ratio odds ratio values were 2.18 (95% confidence interval 1.17-4.41) and 2.14 (95% confidence interval 1.14-4.00) in male patients with T2DF before and after adjusting for age, respectively (P < 0.05).

conclusionsT2DF patients present sex-specific differences in their blood lipid and lipid ratios, especially in the apoB/apoA-I ratio, which could be a better indicator for cardiovascular disease risk.

Indexed as

Sex FactorsAgedApolipoprotein A-IApolipoprotein B-100Body Mass IndexCase-Control StudiesCholesterolCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 2Diabetic FootFemaleGlycated HemoglobinHumansLipidsMaleAPOA1 protein, humanAPOB protein, humanApolipoprotein A-IApolipoprotein B-100CholesterolCholesterol, HDLCholesterol, LDLGlycated Hemoglobinhemoglobin A1c protein, humanLipidsBlood lipids and lipid ratiosDiabetic footSex differences

Identifiers

PMID34137504
PMCPMC8668058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.