ArticleEMBO molecular medicine2021
The global emergence of a novel Streptococcus suis clade associated with human infections.
Article in EMBO molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Article
- Multidrug-resistant and virulent Streptococcus suis strains detected in clinically healthy pigs in Guangdong and Guangxi, China.Veterinary research · 2026Article
- Prokaryotic Expression and Preliminary Application of Lys40, an Endolysin from Broad-Host-Range Salmonella enterica Phage SP_4.Current microbiology · 2026Article
- Gut Microbiome Health in Farm Animals and Fish: Implications for Human Health and the Risk of Gastrointestinal Diseases.Microorganisms · 2026Review
- Right forearm wound and soft tissue abscess complicated with sepsis due to Streptococcus suis: a case report.Frontiers in medicine · 2026Article
- Genomics of Irish swine-derivedMicrobial genomics · 2026Article
- Review
- Article
- Developing genome typing strategies for the emerging zoonotic pathogenJournal of clinical microbiology · 2025Article
- Streptococcus suis in free-ranging wild boars from Southern Brazil: A preliminary survey.Veterinary research communications · 2025Article
- A LXG toxin stabilized by DUF4176 contributes to Streptococcus suis competition and pathogenicity.BMC biology · 2025Article
- STK-mediated FadR phosphorylation regulates the acid resistance and virulence of Streptococcus suis.PLoS pathogens · 2025Article
- Presence of Human-Associated Clade Marker Gene HAC-G19 in Streptococcus suis Isolated From Humans and Swine.Current microbiology · 2025Article
- Population Genomics, Virulence Traits, and Antimicrobial Resistance ofMicroorganisms · 2025Article
- Antimicrobial and antivirulence function of cinnamaldehyde againstMicrobiology spectrum · 2025Article
- Mechanisms Underlying the Effects of Secretory ProteinMicroorganisms · 2025Article
- Current prevalence and therapeutic strategies for porcineApplied and environmental microbiology · 2025Review
- Article
- Decadal advances and future prospects in subunit vaccine development againstFrontiers in immunology · 2025Review
- Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross-species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large-scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human-associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub-lineages and contains several healthy-pig isolates that display high virulence in experimental infections, suggesting healthy-pig carriers as a potential source for human infection. New HAC-specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human-associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide.
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