ArticleeLife2021
A functional model of adult dentate gyrus neurogenesis.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Ablated Sonic Hedgehog Signaling in the Dentate Gyrus of the Dorsal and Ventral Hippocampus Impairs Hippocampal-Dependent Memory Tasks and Emotion in a Rat Model of Depression.Molecular neurobiology · 2024Article
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus.PLoS computational biology · 2024Article
- Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke.Frontiers in pharmacology · 2024Article
- Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice.Communications biology · 2023Article
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
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Authors and funding
2 authors.
Funding
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Abstract
In adult dentate gyrus neurogenesis, the link between maturation of newborn neurons and their function, such as behavioral pattern separation, has remained puzzling. By analyzing a theoretical model, we show that the switch from excitation to inhibition of the GABAergic input onto maturing newborn cells is crucial for their proper functional integration. When the GABAergic input is excitatory, cooperativity drives the growth of synapses such that newborn cells become sensitive to stimuli similar to those that activate mature cells. When GABAergic input switches to inhibitory, competition pushes the configuration of synapses onto newborn cells toward stimuli that are different from previously stored ones. This enables the maturing newborn cells to code for concepts that are novel, yet similar to familiar ones. Our theory of newborn cell maturation explains both how adult-born dentate granule cells integrate into the preexisting network and why they promote separation of similar but not distinct patterns.
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Registered trials
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