Evidence map›Paper›PMID 34137143›Full record

ArticleInternational journal of clinical practice2021

Can prognostic nutritional index and systemic immune-inflammatory index predict disease severity in COVID-19?

Ahmet Nalbant, Taner Demirci, Tezcan Kaya, Ayhan Aydın, Mustafa Altındiş, Ertuğrul Güçlü

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Article in International journal of clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The relationship of the systemic immune inflammation index to severity in chronic spontaneous urticaria.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmet NalbantDepartment of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0003-4756-3575
Taner DemirciDepartment of Endocrinology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-9579-4530
Tezcan KayaDepartment of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0003-0483-2333
Ayhan AydınDepartment of Internal Medicine, Sakarya University Teaching and Education Hospital, Sakarya, Turkey.ORCID https://orcid.org/0000-0001-5231-3533
Mustafa AltındişDepartment of Medical Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0003-0411-9669
Ertuğrul GüçlüDepartment of Infectious Diseases, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0003-2860-2831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognostic nutritional index (PNI) and systemic immune-inflammatory index (SII) are inflammation-based novel markers that predict the prognosis in various patient populations. We have investigated the relationship between the disease severity in COVID-19, and the PNI and SII scores in the present study. MATERIALS AND

methodsThis cross-sectional retrospective study included 118 hospitalised patients with a confirmed diagnosis of COVID-19. The patients were divided into two groups as those who were hospitalised at the intensive care unit (ICU) and those who had been internalised at the clinic (non-ICU).

resultsOf the 118 patients, 50.8% were male. The mean age was 57.7 ± 17.5 years in non-ICU patients and 70.3 ± 11.7 years in ICU patients and the difference was statistically significant (P < .001). The lymphocyte count and the albumin levels were significantly lower in ICU patients (P < .001, P < .001, respectively). The PNI score was significantly lower in ICU patients compared with non-ICU patients (P < .001). The SII score was found to be significantly higher in ICU patients compared with non-ICU patients (P < .001). The value of PNI and SII scores in prediction of the disease severity in COVID-19 was evaluated with the ROC analysis (PNI: AUC = 0.796, 95%CI: 0.715-0.877, P < .001; SII: AUC =0.689, 95% CI: 0.559-0.819, P=.004). When the cut-off value was taken as ≤36.7 for the PNI score, it was found to have 73.4% sensitivity and 70.8% specificity for predicting of the disease severity and ICU admission probability was 4.4 times higher. When the cut-off value was taken as ≥813.6 for SII score, it was found to have 70.8% sensitivity and 66.0% specificity for predicting of the disease severity and ICU admission probability was six times higher.

conclusionThe PNI and the SII scores are independent predictors of the prognosis and the disease severity in COVID-19 patients who require hospitalisation at the ICU.

Indexed as

COVID-19Nutrition AssessmentAdultAgedCross-Sectional StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSARS-CoV-2Severity of Illness Index

Identifiers

PMID34137143
PMCPMC8420107

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.