Evidence map›Paper›PMID 34137029›Full record

ArticleBritish journal of haematology2021

Thromboembolic risk in patients with lung cancer receiving systemic therapy.

Cecelia J Madison, Ryan A Melson, Michael J Conlin, Kenneth R Gundle, Reid F Thompson, David C Calverley

Open access · greenAbstract read
In one paragraph

Article in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Cecelia J MadisonVA Portland Healthcare System, Portland, OR, USA.ORCID 0000-0002-0261-0414
Ryan A MelsonVA Portland Healthcare System, Portland, OR, USA.
Michael J ConlinVA Portland Healthcare System, Portland, OR, USA.
Kenneth R GundleVA Portland Healthcare System, Portland, OR, USA.ORCID 0000-0003-0451-0561
Reid F ThompsonVA Portland Healthcare System, Portland, OR, USA.ORCID 0000-0003-3661-5296
David C CalverleyVA Portland Healthcare System, Portland, OR, USA.
Oregon Health & Science University · USVA Portland Health Care System · USBC Cancer Agency · CA

Funding

Quantifying and improving radiotherapy outcomes among VeteransIK2CX002049 · VA · PORTLAND VA MEDICAL CENTER · PI THOMPSON, REID · 2020 to 2025
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CSRD VA IK2 CX002049
6 · The paper itself

Abstract

In this retrospective study, we investigated the influence of chemotherapy and immunotherapy on thromboembolic risk among United States Veterans with lung cancer during their first 6 months (180 days) following initiation of systemic therapy. Included patients received treatment with common front-line agents that were divided into four groups: chemotherapy alone, immunotherapy alone, combination of chemo- and immunotherapies, and molecularly targeted therapies (control group). The cohort experienced a 7·4% overall incidence of thrombosis, but the analysis demonstrated significantly different rates among the different groups. We explored models incorporating multiple confounding variables as well as the competing risk of death, and these results indicated that both chemo- and immunotherapies were associated with an increased incidence of thrombosis, either alone or combined, compared with the control group (7·56%, P = 2.2 × 10

Indexed as

AdultAgedAged, 80 and overAnticoagulantsAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyConfounding Factors, EpidemiologicFemaleHumansImmunotherapyIncidenceLung NeoplasmsMaleMiddle AgedModels, BiologicalRetrospective StudiesAnticoagulantsanticoagulationchemotherapyimmunotherapylung cancerthromboembolism

Identifiers

PMID34137029
PMCPMC8283785
OpenAlexW3168255462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.