Evidence map›Paper›PMID 34136989›Full record

ReviewEuropean radiology experimental2021

Emerging magnetic resonance imaging techniques in open spina bifida in utero.

Andras Jakab, Kelly Payette, Luca Mazzone, Sonja Schauer, Cécile Olivia Muller, Raimund Kottke, Nicole Ochsenbein-Kölble, Ruth Tuura, Ueli Moehrlen, Martin Meuli

Open access · goldAbstract readReview
In one paragraph

Review in European radiology experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. TMagnetic resonance in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Andras Jakab *Center for MR-Research, University Children's Hospital Zürich, Zürich, Switzerland. Andras.jakab@kispi.uzh.ch.ORCID 0000-0001-6291-9889
Kelly Payette *Center for MR-Research, University Children's Hospital Zürich, Zürich, Switzerland.
Luca MazzoneDepartment of Pediatric Surgery, University Children's Hospital Zurich, Zürich, Switzerland.
Sonja SchauerDepartment of Pediatric Surgery, University Children's Hospital Zurich, Zürich, Switzerland.
Cécile Olivia MullerDepartment of Surgery, Cantonal Hospital of Aarau, Aarau, Switzerland.
Raimund KottkeDepartment of Diagnostic Imaging, University Children's Hospital Zurich, Zurich, Switzerland.
Nicole Ochsenbein-KölbleDepartment of Obstetrics, University Hospital Zurich, Zürich, Switzerland.
Ruth TuuraCenter for MR-Research, University Children's Hospital Zürich, Zürich, Switzerland.
Ueli MoehrlenDepartment of Pediatric Surgery, University Children's Hospital Zurich, Zürich, Switzerland.
Martin MeuliDepartment of Pediatric Surgery, University Children's Hospital Zurich, Zürich, Switzerland.
University of Zurich · CHUniversity Children's Hospital Zurich · CHCenter for Pediatric Endocrinology Zurich · CHKantonsspital Aarau · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) has become an essential diagnostic modality for congenital disorders of the central nervous system. Recent advancements have transformed foetal MRI into a clinically feasible tool, and in an effort to find predictors of clinical outcomes in spinal dysraphism, foetal MRI began to unveil its potential. The purpose of our review is to introduce MRI techniques to experts with diverse backgrounds, who are involved in the management of spina bifida. We introduce advanced foetal MRI postprocessing potentially improving the diagnostic work-up. Importantly, we discuss how postprocessing can lead to a more efficient utilisation of foetal or neonatal MRI data to depict relevant anatomical characteristics. We provide a critical perspective on how structural, diffusion and metabolic MRI are utilised in an endeavour to shed light on the correlates of impaired development. We found that the literature is consistent about the value of MRI in providing morphological cues about hydrocephalus development, hindbrain herniation or outcomes related to shunting and motor functioning. MRI techniques, such as foetal diffusion MRI or diffusion tractography, are still far from clinical use; however, postnatal studies using these methods revealed findings that may reflect early neural correlates of upstream neuronal damage in spinal dysraphism.

Indexed as

Spina Bifida CysticaSpinal DysraphismDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansMagnetic Resonance ImagingDiffusion tensor imagingFoetusInfant (newborn)Magnetic resonance imagingSpinal dysraphism

Identifiers

PMID34136989
PMCPMC8209133
OpenAlexW3172257095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.