ArticleInternational journal of basic and clinical immunology2020
Possible novel non-invasive biomarker for inflammation mediated pancreatic malignancy.
Article in International journal of basic and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPancreatic malignancy is a major public health problem worldwide and recent reports indicated that pancreatic cancer will be second most common cause of cancer-related deaths by the end of 2021. The cause of increasing death rate is due to the nonexistence of detection tools to early diagnose, poor prognosis, resistance to chemotherapy and also lack in understanding the mechanism of PDAC pathogenesis. Circulating tumor cells (CTCs) play a major role in metastatic step of intravasation and presence of these cells are strong prognostic marker for the progression of pancreatic malignancy in chronic pancreatitis (CP). GOAL: Identifying the novel CTCs in the chronic inflammation mediated experimental model for the progression of malignancy in CP.
methodsWe have performed flow cytometer and immunofluorescence analyses in the lymphoid and lung samples was performed o detect CTCs in the chronic inflammation induced mouse model CP.
resultsWe report that induced SOX9 positive cells were observed in the blood, lymph node and spleen samples of cerulein with azoximethane (AOM) treated mouse model of CP compared to cerulein alone. Further, we provide evidence that early metastasis through the migration and homing of mega merged SOX9
conclusionsTaken together, the presented data of identified mega merged SOX9
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34136883PMC8204699W3170151480What OpenQuestion holds
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