Evidence map›Paper›PMID 34136821›Full record

ArticleCritical care explorations2021

Carotid Doppler Measurement Variability in Functional Hemodynamic Monitoring: An Analysis of 17,822 Cardiac Cycles.

Jon-Émile S Kenny, Igor Barjaktarevic, David C Mackenzie, Mai Elfarnawany, Zhen Yang B Math, Andrew M Eibl, Joseph K Eibl, Chul Ho Kim, Bruce D Johnson

Abstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Is the Carotid Artery a Window to the Left Ventricle?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jon-Émile S KennyHealth Sciences North Research Institute, Sudbury, ON, Canada.
Igor BarjaktarevicDivision of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
David C MackenzieDepartment of Emergency Medicine, Maine Medical Center, Portland, ME.
Mai ElfarnawanyFlosonics Medical, Toronto, ON, Canada.
Zhen Yang B MathHealth Sciences North Research Institute, Sudbury, ON, Canada.
Andrew M EiblHealth Sciences North Research Institute, Sudbury, ON, Canada.
Joseph K EiblHealth Sciences North Research Institute, Sudbury, ON, Canada.
Chul Ho KimNorthern Ontario School of Medicine, Sudbury, ON, Canada.
Bruce D JohnsonNorthern Ontario School of Medicine, Sudbury, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid Doppler ultrasound is used as a measure of fluid responsiveness, however, assessing change with statistical confidence requires an adequate beat sample size. The coefficient of variation helps quantify the number of cardiac cycles needed to adequately detect change during functional hemodynamic monitoring.

designProspective, observational, human model of hemorrhage and resuscitation.

settingHuman physiology laboratory at Mayo Clinic. SUBJECTS: Healthy volunteers.

interventionsLower body negative pressure. MEASUREMENTS AND MAIN

resultsWe measured the coefficient of variation of the carotid artery velocity time integral and corrected flow time during significant cardiac preload changes. Seventeen-thousand eight-hundred twenty-two cardiac cycles were analyzed. The median coefficient of variation of the carotid velocity time integral was 8.7% at baseline and 11.9% during lowest-tolerated lower body negative pressure stage. These values were 3.6% and 4.6%, respectively, for the corrected flow time.

conclusionsThe median coefficient of variation values measured in this large dataset indicates that at least 6 cardiac cycles should be averaged before and after an intervention when using the carotid artery as a functional hemodynamic measure.

Indexed as

carotid Dopplercorrected flow timefluid responsivenessmeasurement variabilityvelocity time integral

Identifiers

PMID34136821
PMCPMC8202589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.