ArticleKidney medicine
Urine Biomarkers of Kidney Tubule Health and Incident CKD Stage 3 in Women Living With HIV: A Repeated Measures Study.
Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Trial
- Associations of repeated measures of plasma biomarkers of kidney tubular health with longitudinal kidney function in people with HIV.AIDS (London, England) · 2026Article
- Evolution of kidney function after five years of follow-up in a large Spanish cohort of patients with HIV: risk factors for progression.BMC infectious diseases · 2025Observational
- Urine Epidermal Growth Factor and Kidney Function Decline in Middle-Aged Adults.Kidney medicine · 2024Article
- Associations of Urine Biomarkers of Kidney Tubule Health With Incident Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The CARDIA Study.Hypertension (Dallas, Tex. : 1979) · 2023Article
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
RATIONALE &
objectiveSingle measurements of urinary biomarkers reflecting kidney tubule health are associated with chronic kidney disease (CKD) risk in HIV infection, but the prognostic value of repeat measurements over time is unknown. STUDY
designCohort study. SETTING &
participants647 women living with HIV infection enrolled in the Women's Interagency Health Study. EXPOSURES: 14 urinary biomarkers of kidney tubule health measured at 2 visits over a 3-year period. OUTCOME: Incident CKD, defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m ANALYTICAL APPROACH: We used multivariable generalized estimating equations adjusting for CKD risk factors to evaluate baseline, time-updated, and change-over-time biomarker associations with incident CKD. We compared CKD discrimination between models with and without a parsimoniously selected set of biomarkers.
resultsDuring a median 7 years of follow-up, 9.7% (63/647) developed CKD. In multivariable-adjusted analyses, 3 of 14 baseline biomarkers associated with incident CKD. In contrast, 10 of 14 time-updated biomarkers and 9 of 14 biomarkers modeled as change over time associated with incident CKD. Urinary epidermal growth factor (EGF), α LIMITATIONS: Observational design, incident CKD definition limited to eGFR.
conclusionsRepeat urinary biomarker measurements for kidney tubule health have stronger associations with incident CKD compared with baseline measurements and moderately improve CKD discrimination in women living with HIV infection.
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