Evidence map›Paper›PMID 34136775›Full record

ArticleEClinicalMedicine2021

PERFORM: Pulmonary embolism risk score for mortality in computed tomographic pulmonary angiography-confirmed patients.

Shuili Yu, Honglu Zhou, Yang Li, Jianfeng Song, Jinyan Shao, Xuanyi Wang, Zichen Xie, Chao Qiu, Keyu Sun

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613855 (Performance of Pulmonary Embolism Risk Scores for Assessment of Outcome in Computed Tomographic Pulmonary Angiography Confirmed Patients), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05613855 unknown statusnot on this mapstarted 2022, after this paper: background citation

Performance of Pulmonary Embolism Risk Scores for Assessment of Outcome in Computed Tomographic Pulmonary Angiography Confirmed Patients

TypeobservationalSponsorAssiut UniversityRan2022 to 2024Enrolled60ConditionsPulmonary Embolism
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Classification and Stratification of Pulmonary Embolisms.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuili YuMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Honglu ZhouMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yang LiMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jianfeng SongMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jinyan ShaoMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xuanyi WangMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zichen XieMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Chao QiuMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Keyu SunMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent prognostic scores for pulmonary embolism (PE) were partly based on patients without PE confirmation via computed tomographic pulmonary angiography (CTPA), involving subjective parameters and complicated scoring methods. Therefore, we sought to develop an objective, accurate, and simple prognostic model in CTPA-confirmed patients to predict the risk of 30-day mortality.

methodsWe retrospectively evaluated 509 patients with objectively confirmed PE by CTPA from 2010 to 2017 in the Minhang Hospital, which is affiliated to Fudan University. Patients were randomly divided into the training and validation cohorts. The primary end point was 30-day mortality. The secondary end points were the time to recovery in 30 days and mortality in 15 days. We compared the predictive performance of Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and the PE risk score we developed, called PERFORM.

findingsPERFORM (ranging from 0 to 12 score) is based on the patient's age, heart rate, and partial pressure of arterial oxygen. The area under the curve was 0.718 (95% confidence interval [CI], 0.627-0.809) for the training cohort and 0.906 (95% CI, 0.846-0.966) for the validation cohort. PERFORM was as good as PESI and sPESI in predicting mortality. Patients in the low-risk group (PERFORM score < 5) had a shorter time to recovery, whereas those in the high-risk group (PERFORM score ≥ 5) had a high mortality.

interpretationPERFORM in CTPA-confirmed patients is an objective, accurate, and simple tool to predict the risk of 30-day mortality.

fundingResearch Project of Shanghai Municipal Commission of Health and Family Planning (201740127), Shanghai Medical Key Subject Construction Project (ZK2019B08).

Indexed as

AUC, area under the curveCI, confidence intervalCTPACTPA, computed tomographic pulmonary angiographyICD, International Classification of DiseasesMortalityOR, odds ratioPE, pulmonary embolismPERFORM, pulmonary embolism risk score for mortalityPESI, Pulmonary Embolism Severity IndexPrognosisPulmonary embolismRisk scoreROC, receiver operating characteristicsPESI, simplified Pulmonary Embolism Severity Index

Identifiers

PMID34136775
PMCPMC8181188

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.