ArticleChronic diseases and translational medicine2021
National trends in insulin resistance and β-cell dysfunction among adults with prediabetes: NHANES 2001-2016.
Article in Chronic diseases and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- The Prognostic Role of C-Reactive Protein-Triglyceride Glucose Index in Predicting Unfavorable Outcomes in Acute Ischemic Stroke: A Large-Scale Cohort Study.Brain and behavior · 2026Article
- Leisure-Time Physical Activity Trajectories across Adulthood and Cardiometabolic Risk at the Beginning of Late Adulthood: A Prospective Cohort Study.Medicine and science in sports and exercise · 2026Article
- Estimated glucose disposal rate predicts frailty through diabetes: Evidence from machine learning and mediation models in NHANES.PloS one · 2025Article
- Insufficient compensatory pancreatic β-cells function might be closely associated with hyperuricemia in U.S. adults: evidence from the National Health and Nutrition Examination Survey.BMC public health · 2024Article
- Development and application of a novel model to predict the risk of non-alcoholic fatty liver disease among lean pre-diabetics with normal blood lipid levels.Lipids in health and disease · 2022Article
- Total and regional fat-to-muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes.Journal of cachexia, sarcopenia and muscle · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance is the central abnormality and mechanism underlying the progression of cardiometabolic-based chronic diseases. This study aimed to evaluate the trends in insulin resistance and β-cell dysfunction from 2001 to 2016 among US adults with undiagnosed diabetes, prediabetes, and normal glucose regulation and to provide sex-specific information using data from National Health and Nutrition Examination Surveys (NHANES) 2001-2016.
methodsData from 14,481 participants aged over 20 years from 8 consecutive 2-year cross-sectional cycles of the NHANES from 2001 to 2016 were used. Updated homoeostasis model assessment 2 (HOMA2: HOMA2%B for β-cell function and HOMA2IR for insulin resistance) was used as a surrogate measure. We defined the upper sex-specific tertile of HOMA2IR as insulin resistance and the lower corresponding tertile of HOMA2%B as low β-cell function.
resultsIn both sexes with undiagnosed diabetes, HOMA2%B (men,
conclusionsOver 16 years, insulin resistance demonstrated an increasing trend in adult US population with prediabetes, while β-cell function showed a compensatory increasing trend. Identifying people with prediabetes early and focusing on reducing insulin resistance as the intervention core, especially controlling central obesity, might increase the opportunity for cardiovascular and diabetes risk reduction.
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