Evidence map›Paper›PMID 34136761›Full record

ArticleACS applied bio materials2020

A Rationally Designed Micellar Nanocarrier for the Delivery of Hydrophilic Methotrexate in Psoriasis Treatment.

Dandan Guo, Changying Shi, Lili Wang, Xiaotian Ji, Shengle Zhang, Juntao Luo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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  12. "Click" amphotericin B in prodrug nanoformulations for enhanced systemic fungemia treatment.Journal of controlled release : official journal of the Controlled Release Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dandan GuoDepartment of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
Changying ShiDepartment of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
Lili WangDepartment of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
Xiaotian JiDepartment of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
Shengle ZhangDepartment of Pathology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
Juntao LuoDepartment of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA.
SUNY Upstate Medical University · US

Funding

Novel Anti-HCMV StrategiesR01HL139824 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI CHAN, GARY CHING TAO · 2018 to 2021
$3.0M
An innovative hemoperfusion nanotrap for sepsis treatment.R01GM130941 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI LUO, JUNTAO · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL139824NIGMS NIH HHS R01 GM130941
6 · The paper itself

Abstract

Methotrexate (MTX) is broadly applied in the clinic for the treatments of cancers and autoimmune diseases. Targeted delivery of MTX is attractive to improve its efficacy and reduce off-target toxicity. However, MTX encapsulation in nanoparticle is challenging due to its high water solubility. We rationally designed a well-defined telodendrimer (TD) nanocarrier based on MTX structure to sequester it in nanoparticles. Riboflavin (Rf) and positive charges groups were precisely conjugated on TD to form multivalent hydrogen bonds, π-π stacking and electrostatic interactions with MTX. A reverse micelle approach was developed to preset MTX and TD interactions in the core of micelles, which ensures the effective MTX loading upon dispersion into aqueous solution. As results, MTX loading capacity reaches over 20% (w/w) in the optimized nanocarrier with the particle size of 20-30 nm. The nanoformulations sustain the release of MTX in a controlled manner and exhibit excellent hemocompatibility. The

Indexed as

Drug deliveryMethotrexateNanocarrier designPsoriasis treatmentTelodendrimer

Identifiers

PMID34136761
PMCPMC8204631
OpenAlexW3044313311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.