Evidence map›Paper›PMID 34136489›Full record

ArticleFrontiers in cell and developmental biology2021

CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene

Iveta Gažová, Lucas Lefevre, Stephen J Bush, Rocio Rojo, David A Hume, Andreas Lengeling, Kim M Summers

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Iveta GažováThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
Lucas LefevreThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
Stephen J BushThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
Rocio RojoThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
David A HumeMater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Andreas LengelingThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
Kim M SummersThe Roslin Institute, University of Edinburgh, Easter Bush, United Kingdom.
Roslin Institute · GBUniversity of Edinburgh · GBTranslational Research Institute · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

USP16 is a histone deubiquitinase which facilitates G2/M transition during the cell cycle, regulates DNA damage repair and contributes to inducible gene expression. We mutated the

Indexed as

epigenetic modificationsgenome editinghistone deubiquitinasesmacrophagemonocyteTHP-1 cell lineUSP16 gene

Identifiers

PMID34136489
PMCPMC8203323
OpenAlexW3169808322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.