Evidence map›Paper›PMID 34136484›Full record

ArticleFrontiers in cell and developmental biology2021

SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules.

Zhaohui Chen, Junyi Hu, Lilong Liu, Rong Chen, Miao Wang, Ming Xiong, Zhen-Qiong Li, Yi Zhao, Hong Li, Chuhuai Guan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A survey of SARS-CoV-2 tropism.Infectious diseases & immunity · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. SARS-CoV-2 and the DNA damage response.The Journal of general virology · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Mechanisms and treatment of COVID-19-associated acute kidney injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Predicting mortality in hospitalized COVID-19 patients.Internal and emergency medicine · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Zhaohui ChenDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Junyi HuDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lilong LiuDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rong ChenDepartment of Pathology, Jin Yin-tan Hospital, Wuhan, China.
Miao WangDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ming XiongDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhen-Qiong LiDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi ZhaoDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hong LiDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chuhuai GuanDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Jie ZhangDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Liang LiuDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Ke ChenDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yu-Mei WangDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Union Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We found that angiotensin-converting enzyme II (ACE2) and transmembrane protease serine 2 (TMPRSS2) were mainly expressed by different cell types in the human kidney. However, in autopsy kidney samples, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoprotein was detected in ACE2

Indexed as

ACE2AKICOVID-19RNAscopeSARS-CoV-2TMPRSS2

Identifiers

PMID34136484
PMCPMC8201778
OpenAlexW3166974598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.