Evidence map›Paper›PMID 34136393›Full record

ArticleFrontiers in oncology2021

Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits.

Krishna Patel, Firdous Ahmad Bhat, Shankargouda Patil, Samapika Routray, Neeta Mohanty, Bipin Nair, David Sidransky, Mandakulutur S Ganesh, Jay Gopal Ray, Harsha Gowda and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Krishna PatelInstitute of Bioinformatics, International Technology Park, Bangalore, India.
Firdous Ahmad BhatInstitute of Bioinformatics, International Technology Park, Bangalore, India.
Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Samapika RoutrayDepartment of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha' O' Anusandhan University, Bhubaneswar, India.
Neeta MohantyDepartment of Oral Pathology & Microbiology, Institute of Dental Sciences, Siksha' O' Anusandhan University, Bhubaneswar, India.
Bipin NairAmrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India.
David SidranskyDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Mandakulutur S GaneshDepartment of Surgical Oncology, Vydehi Institute of Oncology, Bangalore, India.
Jay Gopal RayDepartment of Oral Pathology, Dr. R. Ahmed Dental College & Hospital, Kolkata, India.
Harsha GowdaInstitute of Bioinformatics, International Technology Park, Bangalore, India.
Aditi ChatterjeeInstitute of Bioinformatics, International Technology Park, Bangalore, India.
Amrita Vishwa Vidyapeetham · INSiksha O Anusandhan University · INDr. R. Ahmed Dental College and Hospital · INInstitute of Bioinformatics · INJazan University · SAJohns Hopkins Medicine · USManipal Academy of Higher Education · INQIMR Berghofer Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a common cancer of the oral cavity in India. Cigarette smoking and chewing tobacco are known risk factors associated with OSCC. However, genomic alterations in OSCC with varied tobacco consumption history are not well-characterized. In this study, we carried out whole-exome sequencing to characterize the mutational landscape of OSCC tumors from subjects with different tobacco consumption habits. We identified several frequently mutated genes, including

Indexed as

genome aberrationHNSCCM-class cancermutational signatureoral cancer

Identifiers

PMID34136393
PMCPMC8200776
OpenAlexW3167923801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.