Evidence map›Paper›PMID 34136093›Full record

ArticleComputational and structural biotechnology journal2021

Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.

Francesca Paoletti, Franci Merzel, Alberto Cassetta, Iza Ogris, Sonia Covaceuszach, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Francesca PaolettiLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.
Franci MerzelLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.
Alberto CassettaInstitute of Crystallography - C.N.R.- Trieste Outstation. Area Science Park - Basovizza, S.S.14 - Km. 163.5, I-34149 Trieste, Italy.
Iza OgrisLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.
Sonia CovaceuszachInstitute of Crystallography - C.N.R.- Trieste Outstation. Area Science Park - Basovizza, S.S.14 - Km. 163.5, I-34149 Trieste, Italy.
Jože GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.
Doriano LambaInstitute of Crystallography - C.N.R.- Trieste Outstation. Area Science Park - Basovizza, S.S.14 - Km. 163.5, I-34149 Trieste, Italy.
Simona Golič GrdadolnikLaboratory for Molecular Structural Dynamics, Theory Department, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.
National Institute of Chemistry · SIAREA Science Park · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Nerve Growth Factor (NGF) neurotrophin acts in the maintenance and growth of neuronal populations. Despite the detailed knowledge of NGF's role in neuron physiology, the structural and mechanistic determinants of NGF bioactivity modulated by essential endogenous ligands are still lacking. We present the results of an integrated structural and advanced computational approach to characterize the extracellular ATP-NGF interaction. We mapped by NMR the interacting surface and ATP orientation on NGF and revealed the functional role of this interaction in the binding to TrkA and p75

Indexed as

ARIA, Ambiguous Restraints for Iterative AssignmentATP modulationBDNF, Brain Derived Neurotrophic FactorCARA, Computer Aided Resonance AssignmentCS-E, Chrondroitin Sulfate ECSP, Chemical Shift PerturbationDSF, Differential Scanning FluorimetryEI-MS, Electron Ionization Mass SpectrometryEndogenous ligandsFGF2, Fibroblast Growth Factor 2FT-IR, Fourier Transform Infrared SpectroscopyHBD, Heparin Binding DomainHSQC, Heteronuclear Single Quantum CoherenceITC, Isothermal Titration CalorimetryMALDI-TOF MS, Matrix Assisted Laser Desorption Ionization-Time Of Flight Mass SpectrometryMD, Molecular DynamicsMS, Mass SpectrometryNeurotrophinsNGF interactionsNGF, Nerve Growth FactorNMR, Nuclear Magnetic ResonanceNOE, Nuclear Overhouser EffectNOESY, Nuclear Overhauser Effect SpectroscopyNT, NeuroTrophinP20, Polysorbate 20p75NTR, p75 NeuroTrophin ReceptorPME, Particle Mesh EwaldproNGF, proNGF – NGF precursorrhNGF, recombinant human NGFrh-proNGF, recombinant human proNGF – NGF precursorrmNGF, recombinant mouse NGFRMSD, Root Mean Square DeviationSAR, Structure-Activity RelationshipSPR, Surface Plasmon ResonanceSTD, Saturation-Transfer DifferenceTrkA, p75NTR receptorsTrkA, Tyrosine Kinase Receptor A

Identifiers

PMID34136093
PMCPMC8164016
OpenAlexW3162499020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.