ReviewInternational journal of dentistry2021
MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis.
Review in International journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Effect of Endodontic Sealers on the Bond Strength of Glass Fibre Posts: A Systematic Review.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Pooled it
- Proteolytic enzymes in dentin erosion: roles of matrix metalloproteinases and cathepsins and the effectiveness of synthetic and natural inhibitors-a systematic review.BMC oral health · 2026Pooled it
- Clinical performance of the ethanol-wet bonding technique with different adhesive systems in noncarious cervical lesion restorations: a 6-year randomized clinical trial.Clinical oral investigations · 2026Trial
- Trial
- Influence of Different Cavity Disinfection Protocols on Adhesion at the Resin Composite-Dentin Interface.Polymers · 2026Article
- Application of a chlorinated catechol monomer to enhance dentin bond durability and impart antibacterial activity.BMC oral health · 2026Article
- Transdentinal effects of flavonoid-based primers applied to caries-affected dentin on pulp cells.Clinical oral investigations · 2025Review
- Marginal integrity produced by quaternary ammonium methacrylate-based dental adhesive tested under physiologically relevant models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Therapeutic potential of flavonoids in erosive tooth wear management: a scoping review.Clinical oral investigations · 2025Article
- Article
- 12 Months Results of Bond Strength and Endogenous Enzymatic Activity of Radicular Dentin Obturated With Bioceramic Sealer.The journal of adhesive dentistry · 2025Article
- Evaluation of the effect of gallic acid dentin treatment on the shear bond strength of the composite resin by using universal adhesive, in self-etch and total-etch strategies.Journal of clinical and experimental dentistry · 2025Article
- Dual-Mode Antibacterial Orthodontic Composite: Contact-Killing QACs and Sustained CHX Release via Large-Pore Mesoporous Silica Nanoparticles.International journal of molecular sciences · 2025Article
- Effect of Matrix Metalloproteinase Inhibitors on the Dentin Bond Strength and Durability of a Two-Step Universal Adhesive System.Journal of clinical and experimental dentistry · 2025Article
- Enhancing adhesive performance with N, N, N', N'-tetrakis (2-pyridyl methyl) ethylenediamine matrix metalloproteinase inhibitors: A comprehensive study of degree of conversion, microleakage, and micro-tensile bond strength in dental adhesives.Journal of conservative dentistry and endodontics · 2025Article
- Effect of Pre-Procedural Antiseptic Mouthwash On The Dentin Bond Strength of Dental Adhesives.The journal of adhesive dentistry · 2025Article
- Preservation Strategies for Interfacial Integrity in Restorative Dentistry: A Non-Comprehensive Literature Review.Journal of functional biomaterials · 2025Review
- Metalloproteinases (MMPs) in hypertensive disorders: role, function, pharmacology, and potential strategies to mitigate pathophysiological changes.Frontiers in pharmacology · 2025Review
- Evaluation of Monomer-containing Isocyanate Groups on Stabilizing Demineralized Dentin Matrix Against Bond Interface Degradation.The journal of adhesive dentistry · 2024Article
- Influence of chlorhexidine dentin disinfection on universal adhesive performance: Interfacial adaptation and bond strength assessments.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesResin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix of the hybrid layer. Various MMP inhibitors with the ability to prevent enzymatic degradation have been identified. This study aimed to systematically review the literature for studies which evaluated the effect of MMP inhibitors on the immediate and aged dentin bond strengths.
conclusionsA clear trend for a lower loss of dentin bond strength was observed with different MMP inhibitors. In meta-analysis, no significant difference was seen between the CHX and control in the immediate bond strengths. Bond strengths in the CHX group were significantly higher than the control group after aging (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.