Evidence map›Paper›PMID 34135904›Full record

ArticleFrontiers in immunology2021

FasL Is Required for Osseous Healing in Extraction Sockets in Mice.

Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung-Seok Lee, Stefan Tangl, Franz J Strauss, Alexandra Stähli, Eva Matalová, Reinhard Gruber

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. FasL is a catabolic factor in alveolar bone homeostasis.Journal of clinical periodontology · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Karol Alí Apaza AlccayhuamanDepartment of Oral Biology, Medical University of Vienna, Vienna, Austria.
Patrick HeimelKarl Donath Laboratory for Hard Tissue and Biomaterial Research, School of Dentistry, Medical University of Vienna, Vienna, Austria.
Jung-Seok LeeDepartment of Oral Biology, Medical University of Vienna, Vienna, Austria.
Stefan TanglKarl Donath Laboratory for Hard Tissue and Biomaterial Research, School of Dentistry, Medical University of Vienna, Vienna, Austria.
Franz J StraussDepartment of Oral Biology, Medical University of Vienna, Vienna, Austria.
Alexandra StähliDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Eva MatalováInstitute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia.
Reinhard GruberDepartment of Oral Biology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATAustrian Cluster for Tissue Regeneration · ATCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZUniversity of Bern · CHUniversity of Chile · CL

Funding

Austrian Science Fund FWF I 4072
6 · The paper itself

Abstract

Fas ligand (FasL) is a member of the tumor necrosis factor (TNF) superfamily involved in the activation of apoptosis. Assuming that apoptosis is initiated after tooth extraction it is reasonable to suggest that FasL may play a pivotal role in the healing of extraction sockets. Herein, we tested the hypothesis of whether the lack of FasL impairs the healing of extraction sockets. To this end, we extracted upper right incisors of FasL knockout (KO) mice and their wildtype (WT) littermates. After a healing period of two weeks, bone volume over total volume (BV/TV)

Indexed as

Bone RegenerationTooth ExtractionAnimalsBiomarkersBone DensityFas Ligand ProteinImmunohistochemistryMiceModels, AnimalOrgan SizeWound HealingX-Ray MicrotomographyBiomarkersFas Ligand Proteinbone regenarationdentistryfaslhistologyknockout (KO)tooth extractionµCT

Identifiers

PMID34135904
PMCPMC8200669
OpenAlexW3168724780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.