Evidence map›Paper›PMID 34135903›Full record

ArticleFrontiers in immunology2021

Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions.

Lanette Kempers, Evelien G G Sprenkeler, Abraham C I van Steen, Jaap D van Buul, Taco W Kuijpers

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  8. Neutrophils: Amoeboid Migration and Swarming Dynamics in Tissues.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lanette KempersMolecular Cell Biology Laboratory, Department of Molecular and Cellular Haemostasis, Sanquin Research, Amsterdam University Medical Center (AUMC), Amsterdam, Netherlands.
Evelien G G SprenkelerDepartment of Blood Cell Research, Sanquin Research, AUMC, University of Amsterdam, Amsterdam, Netherlands.
Abraham C I van SteenMolecular Cell Biology Laboratory, Department of Molecular and Cellular Haemostasis, Sanquin Research, Amsterdam University Medical Center (AUMC), Amsterdam, Netherlands.
Jaap D van BuulMolecular Cell Biology Laboratory, Department of Molecular and Cellular Haemostasis, Sanquin Research, Amsterdam University Medical Center (AUMC), Amsterdam, Netherlands.
Taco W KuijpersDepartment of Blood Cell Research, Sanquin Research, AUMC, University of Amsterdam, Amsterdam, Netherlands.
Sanquin · NLUniversity of Amsterdam · NLEmma Kinderziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The actin-related protein (ARP) 2/3 complex, essential for organizing and nucleating branched actin filaments, is required for several cellular immune processes, including cell migration and granule exocytosis. Recently, genetic defects in ARPC1B, a subunit of this complex, were reported. Mutations in

Indexed as

MutationActin-Related Protein 2-3 ComplexActinsCase-Control StudiesCell AdhesionCells, CulturedChemotaxisHumansHuman Umbilical Vein Endothelial CellsNeutrophil InfiltrationNeutrophilsPolymerizationPrimary Immunodeficiency DiseasesTransendothelial and Transepithelial MigrationActin-Related Protein 2-3 ComplexActinsARPC1B protein, humanARP2/3 complexARPC1B deficiencyinborn error of immunityneutrophilneutrophil transmigrationprimary immunodeficiencyvessel-on-a-chip

Identifiers

PMID34135903
PMCPMC8202084
OpenAlexW3172199005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.