Evidence map›Paper›PMID 34135734›Full record

ReviewFrontiers in cellular neuroscience2021

Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.

Chang Yin, Eric Peterman, Jeffrey P Rasmussen, Jay Z Parrish

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Heat-off responses of epidermal cells sensitizebioRxiv : the preprint server for biology · 2025
    Article
  3. eLife · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A photo-switchable assay system for dendrite degeneration and repair inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chang YinDepartment of Biology, University of Washington, Seattle, WA, United States.
Eric PetermanDepartment of Biology, University of Washington, Seattle, WA, United States.
Jeffrey P RasmussenDepartment of Biology, University of Washington, Seattle, WA, United States.
Jay Z ParrishDepartment of Biology, University of Washington, Seattle, WA, United States.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Structural and functional coupling of epidermis to somatosensory neurons in DrosophilaR01NS076614 · NINDS · UNIVERSITY OF WASHINGTON · PI BAUTISTA, DIANA MICHELE, PARRISH, JAY Z · 2011 to 2023
$4.2M
Regulation of neuronal morphogenesis and remodeling by the skinR00HD086271 · NICHD · UNIVERSITY OF WASHINGTON · PI RASMUSSEN, JEFFREY PHILIP · 2018 to 2020
$745k
NCI NIH HHS P30 CA015704NICHD NIH HHS R00 HD086271NIDDK NIH HHS P30 DK017047NINDS NIH HHS R01 NS076614
6 · The paper itself

Abstract

Somatosensory neurons (SSNs) densely innervate our largest organ, the skin, and shape our experience of the world, mediating responses to sensory stimuli including touch, pressure, and temperature. Historically, epidermal contributions to somatosensation, including roles in shaping innervation patterns and responses to sensory stimuli, have been understudied. However, recent work demonstrates that epidermal signals dictate patterns of SSN skin innervation through a variety of mechanisms including targeting afferents to the epidermis, providing instructive cues for branching morphogenesis, growth control and structural stability of neurites, and facilitating neurite-neurite interactions. Here, we focus onstudies conducted in worms (

Indexed as

axon and dendrite developmentC. elegansDrosophilaepidermissomatosensory neuronzebrafish

Identifiers

PMID34135734
PMCPMC8200473

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.