ArticleHIV/AIDS (Auckland, N.Z.)2021
Effect of Isoniazid Prophylaxis Therapy on the Prevention of Tuberculosis Incidence and Associated Factors Among HIV Infected Individuals in Northwest Ethiopia: Retrospective Cohort Study.
Article in HIV/AIDS (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Pooled it
- Incidence rate of tuberculosis among HIV infected children in Ethiopia: systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Pooled it
- Effect of isoniazid preventive therapy on tuberculosis incidence and its predictors among adult patients enrolled in antiretroviral therapy at public health facilities in Ambo Town, Oromia, Ethiopia: a retrospective cohort study.BMC infectious diseases · 2026Article
- Clinical Determinants Associated With Viral Load Count Among Adult TB/HIV Co-Infected Patients: A Linear Mixed-Effects Model Analysis.Advances in virology · 2025Article
- Article
- Prediction of precancerous cervical cancer lesions among women living with HIV on antiretroviral therapy in Uganda: a comparison of supervised machine learning algorithms.BMC women's health · 2024Article
- Isoniazid Preventive Therapy Uptake and Its Effect on Tuberculosis Incidence Among People Living with HIV in Illubabor and Buno Bedelle Zones, South-West Ethiopia, 2022: A Retrospective Cohort Study.HIV/AIDS (Auckland, N.Z.) · 2023Article
- Management of Latent Tuberculosis Infection Based on T-SPOT.TB Assay in Patients with Hematological Malignancies.Mediterranean journal of hematology and infectious diseases · 2023Article
- Predictors of a high incidence of opportunistic infections among HIV-infected children receiving antiretroviral therapy at Amhara regional state comprehensive specialized hospitals, Ethiopia: A multicenter institution-based retrospective follow-up study.Frontiers in pediatrics · 2023Article
- Tuberculosis screening coverage and isoniazid preventive therapy among people living with HIV at Gambella Hospital, southwest Ethiopia: a retrospective study design.The Journal of international medical research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreating latent tuberculosis (TB) infection with Isoniazid (INH) among human immune virus (HIV) infected patients reduces active TB occurrence and death by 62% and 26%, respectively. Even though other studies show aforementioned evidence, TB incidence and its associated factors among HIV-infected individuals who were on INH and never on INH is not well studied in northwest Ethiopia. Therefore, this study tried to assess the effect of INH prophylaxis in TB prevention and associated factors among HIV-infected individuals.
methodsData were extracted from charts of HIV-infected clients who completed INH (193) and were never on INH (198) after a simple random sampling selection was done among newly diagnosed patients on follow-up from 2008 to 2015. After data were collected, it was entered into Epi info version 7 and exported to SPSS version 22 for analysis. Cox regression model was fitted and the hazard ratio was reported.
resultsIn this study, the overall TB incidence rate among HIV patients was 3.5/100 person-years (PY) [95% CI: 2.55, 4.82]. But it was 7.1/100 PY among patients who were never on INH and 0.35/100 PY among patients who completed INH. INH completed [adjusted hazard ratio (AHR) = 0.08, 95% CI: 0.02-0.37], on anti-retroviral therapy (ART) [AHR = 0.02, 95% CI: 0.01-0.04], baseline World Health Organization (WHO) stage I & II [AHR =0.22, 95% CI: 0.08-0.62] and baseline CD4 ≤ 350 [AHR=3.76, 95% CI: 1.39-10.18] were significantly associated with TB incidence.
conclusionPutting patients on INH for 6 months and ART were protective factors against TB. Therefore, health institutions are recommended to provide INH after ruling out active TB and contraindications for HIV-infected individuals.
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