ArticleNeuropsychiatric disease and treatment2021
Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank.Sensors (Basel, Switzerland) · 2025Article
- Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke.Frontiers in neurology · 2025Article
- Explore the influencing factors and construct random forest models of post-stroke depression at 3 months in males and females.BMC psychiatry · 2022Article
- Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the correlation between white matter hyperintensity (WMH) and post-stroke depression (PSD) at 3 months, and to further investigate sex differences in the pathogenesis of PSD.
methodsA total of 238 consecutive patients with acute cerebral infarction were recruited. PSD was assessed at 2 weeks and at 3 months after stroke onset. All stroke cases were divided into four subgroups according to the diagnosis of depression at two time nodes: continuous depression; depression remission; late-onset PSD; and continuous non-depression. The Fazekas and Scheltens visual rating scales were adopted to assess WMH.
resultsLogistic regression revealed that the presence of periventricular white matter hyperintensity (PVWMH) at baseline in male patients was an independent risk factor for PSD at 3 months. Further subgroup analysis revealed that PVWMH was associated with late-onset PSD in males, but not with continuous depression 3 months after stroke. Male acute stroke patients with PVWMH at baseline were more likely to develop PSD at 3 months, especially late-onset PSD.
conclusionOur data suggest that sex differences may influence the pathogenesis of PSD.
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