Evidence map›Paper›PMID 34135520›Full record

ArticleNature2021

Localization atomic force microscopy.

George R Heath, Ekaterina Kots, Janice L Robertson, Shifra Lansky, George Khelashvili, Harel Weinstein, Simon Scheuring

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

George R HeathDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6431-2191
Ekaterina KotsDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7139-7098
Janice L RobertsonDepartment of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5499-9943
Shifra LanskyDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
George KhelashviliDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7235-8579
Harel WeinsteinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3473-9818
Simon ScheuringDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA. sis2019@med.cornell.edu.ORCID http://orcid.org/0000-0003-3534-069X

Funding

Enabling physical stimuli in the study of structural dynamics: The sensory ion channelsDP1AT010874 · NCCIH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHEURING, SIMON · 2019 to 2023
$5.9M
Driving forces of membrane protein assembly in membranesR01GM120260 · NIGMS · WASHINGTON UNIVERSITY · PI ROBERTSON, JANICE L · 2016 to 2024
$3.4M
High-speed atomic force microscopy with microsecond time resolution for the study of channels and transportersR01NS110790 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Simon Scheuring · 2019 to 2026
$2.4M
NCCIH NIH HHS DP1 AT010874NIGMS NIH HHS R01 GM120260NINDS NIH HHS R01 NS110790
6 · The paper itself

Abstract

Understanding structural dynamics of biomolecules at the single-molecule level is vital to advancing our knowledge of molecular mechanisms. Currently, there are few techniques that can capture dynamics at the sub-nanometre scale and in physiologically relevant conditions. Atomic force microscopy (AFM)

Indexed as

AlgorithmsAmino AcidsAnnexin A5AquaporinsChloride ChannelsDatasets as TopicEscherichia coli ProteinsHumansHydrogen-Ion ConcentrationMicroscopy, Atomic ForceMolecular Dynamics SimulationAmino AcidsAnnexin A5aqpZ protein, E coliAquaporinsChloride ChannelsClC protein, E coliEscherichia coli Proteins

Identifiers

PMID34135520
PMCPMC8697813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.