ArticleNature2021
Structures of human mGlu2 and mGlu7 homo- and heterodimers.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
85 citing papers in PubMed, 129 citations in OpenAlex.
- Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.Nature communications · 2026Article
- Structural basis for modulation of group III mGlu receptors by transsynaptic interactions.Science advances · 2026Article
- G protein selectivity in group I metabotropic glutamate receptors.Science advances · 2026Article
- Molecular pharmacology of mGluMolecular pharmacology · 2026Article
- Targeting frizzled receptors (FZDs) for anti-tumor therapy: From orthosteric to allosteric inhibition.Acta pharmaceutica Sinica. B · 2026Review
- Subtype-dependent arrestin engagement of the metabotropic glutamate receptors.Nature communications · 2026Article
- Nanobodies unlock new mechanisms to target G protein-coupled receptors.Molecular pharmacology · 2026Review
- Functional and structural basis of a negative allostery within GABANature communications · 2026Article
- CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling.Nature communications · 2026Article
- Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HTNature communications · 2026Article
- GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Glutathione as a taste modulator: molecular mechanisms of interaction with umami and sweet taste receptors.Food chemistry. Molecular sciences · 2025Article
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- Structural Basis of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Structure and activation mechanism of human sweet taste receptor.Cell research · 2025Article
- Domain coupling in activation of a family C GPCR.Nature chemical biology · 2025Article
- Metabotropic glutamate receptor homo- and heterodimers exhibit distinct responses to orthosteric and allosteric ligands.Molecular pharmacology · 2025Article
- Unveiling the molecular mechanism of GProtein science : a publication of the Protein Society · 2025Article
- mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy.Frontiers in bioscience (Landmark edition) · 2025Review
- Life history and chromosome organization determine chemoreceptor gene expression in rattlesnakes.The Journal of heredity · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 3 countries.
Juan Du *State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Dejian Wang *State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Hongcheng Fan *University of Chinese Academy of Sciences, Beijing, China.
Chanjuan Xu *Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-5640-1896
Linhua Tai *University of Chinese Academy of Sciences, Beijing, China.
Shuling Lin *CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Shuo HanState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-0760-0183
Qiuxiang TanCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xinwei WangCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tuo XuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Hui ZhangCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xiaojing ChuCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Cuiying YiState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Peng LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Xiaomei WangKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Yu ZhouState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jean-Philippe PinInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, Montpellier, France.ORCID http://orcid.org/0000-0002-1423-345X
Philippe RondardInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, Montpellier, France.ORCID http://orcid.org/0000-0003-1134-2738
Hong LiuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. hliu@simm.ac.cn.ORCID http://orcid.org/0000-0003-3685-6268
Jianfeng LiuKey Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. jfliu@mail.hust.edu.cn.ORCID http://orcid.org/0000-0002-0284-8377
Fei SunUniversity of Chinese Academy of Sciences, Beijing, China. feisun@ibp.ac.cn.ORCID http://orcid.org/0000-0002-0351-5144
Beili WuCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.ORCID http://orcid.org/0000-0002-1936-0909
Qiang ZhaoState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. zhaoq@simm.ac.cn.ORCID http://orcid.org/0000-0001-6251-6676
Chinese Academy of Sciences · CNCentre National de la Recherche Scientifique · FRGuangzhou Regenerative Medicine and Health Guangdong Laboratory · CNHuazhong University of Science and Technology · CNInstitute of Biophysics · CNShanghaiTech University · CNShanghai Institute of Materia Medica · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic transmission and neuronal excitability in the central nervous system
Indexed as
Cryoelectron MicroscopyHumansProtein MultimerizationProtein Structure, TertiaryReceptors, Metabotropic Glutamatemetabotropic glutamate receptor 2metabotropic glutamate receptor 7Receptors, Metabotropic Glutamate
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.