ArticleNature2021
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 131 citations in OpenAlex.
- MFSD2A in health and disease: lysolipid transport, barrier physiology, and translational boundaries.Molecular biomedicine · 2026Review
- Structural insight into sodium-dependent bile acid transport by members of the SLC10 family.Structure (London, England : 1993) · 2026Article
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- Structure and allostery in major facilitator superfamily symport mechanisms.Acta crystallographica. Section D, Structural biology · 2026Article
- The regulatory network of Mfsd2a in cerebral ischemia: a novel time-targeted intervention framework.Molecular biology reports · 2026Review
- Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B.Nature communications · 2026Article
- Food-Derived Omega-3 Fatty Acids and Cognitive Aging: Integrating Nutritional Neuroscience and Geroscience.Nutrients · 2026Review
- Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter.Research square · 2026Article
- Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter.bioRxiv : the preprint server for biology · 2026Article
- Dual-Responsive Dynamic Covalent Bond-Based Assembly of Lipid-Nanozyme Systems via Multi-Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modulating Blood-Brain Barrier Metabolites of Broiler Chickens Through Dietary Flaxseed Oil.Biomolecules · 2026Article
- Cellular mechanisms of brain lipid metabolism in health and disease.Nature cell biology · 2026Review
- Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mfsd2a is important for maintaining epidermal homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.Journal of neuroinflammation · 2026Article
- Article
- L-Borneolum Attenuates Ischemic Stroke Through Remodeling BBB Transporter Function via Regulating MFSD2A/Cav-1 Signaling Pathway.Brain sciences · 2026Article
- Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B.bioRxiv : the preprint server for biology · 2026Article
- Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mediterranean Diet Adherence Is Associated with Lower Prevalence of Depression and Anxiety in University Students: A Cross-Sectional Study in Greece.Diseases (Basel, Switzerland) · 2026Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 2 countries.
Rosemary J CaterDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Geok Lin ChuaSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.
Satchal K ErramilliDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8694-7681
James E KeenerDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Brendon C ChoyDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7070-073X
Piotr TokarzDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Cheen Fei ChinSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6753-9228
Debra Q Y QuekSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.
Brian KlossCenter on Membrane Protein Production and Analysis, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0130-8739
Joseph G PepeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-2993-1872
Giacomo ParisiDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Bernice H WongSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0001-8981-1376
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1876-196X
Michael T MartyDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-8115-1772
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
George KhelashviliDepartment of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, New York, NY, USA. gek2009@med.cornell.edu.ORCID http://orcid.org/0000-0001-7235-8579
David L SilverSignature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore. david.silver@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-7289-9890
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. fm123@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-3293-2200
Duke-NUS Medical School · SGColumbia University · USUniversity of Chicago · USColumbia University Irving Medical Center · USUniversity of Arizona · USCornell University · USNew York Structural Biology Center · US
Funding
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MStructural basis of integral membrane enzyme functionR35GM132120 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Filippo Mancia · 2019 to 2026
$3.7MUnravelling Membrane Protein-Lipid Interactions using Nanodiscs and Mass SpectrometryR35GM128624 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Michael T Marty · 2018 to 2026
$3.6MMolecular mechanism of omega-3 fatty acid transport into the brainR21MH125649 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANCIA, FILIPPO · 2021 to 2022
$446kNIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R35 GM128624NIGMS NIH HHS R35 GM132120NIMH NIH HHS R21 MH125649
Abstract
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological development and function, and it is supplied to the brain and eyes predominantly from dietary sources
Indexed as
Biological TransportCryoelectron MicroscopyAnimalsBinding SitesBlood-Brain BarrierChickensFatty Acids, Omega-3Mass SpectrometryModels, MolecularMolecular Dynamics SimulationProtein DomainsSodiumSymportersFatty Acids, Omega-3SodiumSymporters
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.