ArticleScientific reports2021
Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- Cortical morphology alterations in non-COVID-19 post-infectious olfactory dysfunction.Scientific reports · 2025Article
- Impact on the microstructure of deep gray matter in unvaccinated patients after moderate-to-severe COVID-19: insights from MRI T1 mapping.European radiology experimental · 2025Article
- Altered white matter architecture in patients with isolated congenital anosmia.Brain structure & function · 2025Article
- Cognitive deficits and cortical volume loss in COVID-19-related hyposmia.European journal of neurology · 2025Article
- Gait dynamics and brain function abnormalities in Parkinson's disease with freezing of gait: a clinical study using resting-state fMRI and wearable devices.Frontiers in neuroscience · 2025Article
- MRI evidence of gray matter loss in COVID-19 patients with cognitive and olfactory disorders.Annals of clinical and translational neurology · 2024Article
- Can Intranasal Insulin and Cholinergic Agonist Improve Post-Covid-19 Cognition Impairment?Advanced pharmaceutical bulletin · 2024Article
- Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex.Human brain mapping · 2023Article
- Brain Volume Changes after COVID-19 Compared to Healthy Controls by Artificial Intelligence-Based MRI Volumetry.Diagnostics (Basel, Switzerland) · 2023Article
- The Impact of Angiotensin-Converting Enzyme-2/Angiotensin 1-7 Axis in Establishing Severe COVID-19 Consequences.Pharmaceutics · 2022Review
- Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction.Brain sciences · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
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Abstract
Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) of these regions in 257 patients. Voxel-based morphometry was applied to measure GMV in brain regions of interest to test the effects of etiology and duration on regional GMV and the relation between olfactory function and regional GMV. Etiology of OL had a significant effect on GMV in clusters representing the gyrus rectus and orbitofrontal cortex (OFC), bilaterally. Patients with congenital anosmia had reduced GMV in the gyrus rectus and an increased OFC volume compared to patients with acquired OL. There was a significant association between volume of the left OFC and olfactory function. This implies that changes in GMV in patients with acquired OL are mainly reflected in the OFC and depend on olfactory function. Morphology of olfactory areas in the brain therefore seems to relate to olfactory function and the subsequent degree of exposure to olfactory input in patients with acquired OL. Differences in GMV in congenital anosmia are most likely due to the fact that patients were never able to smell.
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