Evidence map›Paper›PMID 34135432›Full record

ArticleScientific reports2021

Oral pre-treatment with thiocyanate (SCN

Luke Hall, Chaouri Guo, Sarah Tandy, Kathryn Broadhouse, Anthony C Dona, Ernst Malle, Emil D Bartels, Christina Christoffersen, Stuart M Grieve, Gemma Figtree and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Halogenation Activity of Mammalian Heme Peroxidases.Antioxidants (Basel, Switzerland) · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Luke HallThe Heart Research Institute, Newtown, NSW, 2042, Australia.
Chaouri GuoDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
Sarah TandySchool of Medicine, University of Sydney, Sydney, NSW, 2006, Australia.
Kathryn BroadhouseThe Heart Research Institute, Newtown, NSW, 2042, Australia.
Anthony C DonaSchool of Medicine, University of Sydney, Sydney, NSW, 2006, Australia.
Ernst MalleDivision of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Emil D BartelsDepartment of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Christina ChristoffersenDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
Stuart M GrieveSchool of Medicine, University of Sydney, Sydney, NSW, 2006, Australia.
Gemma FigtreeSchool of Medicine, University of Sydney, Sydney, NSW, 2006, Australia.
Clare L HawkinsDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.
Michael J DaviesThe Heart Research Institute, Newtown, NSW, 2042, Australia. davies@sund.ku.dk.
University of Sydney · AUUniversity of Copenhagen · DKRigshospitalet · DKThe Heart Research Institute · AUMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite improvements in revascularization after a myocardial infarction, coronary disease remains a major contributor to global mortality. Neutrophil infiltration and activation contributes to tissue damage, via the release of myeloperoxidase (MPO) and formation of the damaging oxidant hypochlorous acid. We hypothesized that elevation of thiocyanate ions (SCN

Indexed as

AnimalsCardiac OutputCollagenDietary SupplementsEchocardiographyHeartMaleMetabolomeMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumPeroxidaseRatsRats, Sprague-DawleyThiocyanatesCollagenPeroxidasethiocyanateThiocyanates

Identifiers

PMID34135432
PMCPMC8209016
OpenAlexW3169792698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.