Evidence map›Paper›PMID 34135423›Full record

ArticleScientific reports2021

Evidence of a new hidden neural network into deep fasciae.

Caterina Fede, Lucia Petrelli, Diego Guidolin, Andrea Porzionato, Carmelo Pirri, Chenglei Fan, Raffaele De Caro, Carla Stecco

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06603168 (Autonomic Recalibration Approach to Myofascial Pain Elimination), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06603168 nacompletednot on this mapstarted 2023, after this paper: background citation

Autonomic Recalibration Approach to Myofascial Pain Elimination

TypeinterventionalSponsorEdward Via Virginia College of Osteopathic MedicineRan2023 to 2024Enrolled20ConditionsChronic Pain (Back / Neck), Autonomic DysregulationArmsAutonomic Recalibration Treatment
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Fascial Innervation: A Systematic Review of the Literature.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Caterina Fede *Department of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy. caterina.fede@unipd.it.
Lucia Petrelli *Department of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Diego GuidolinDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Andrea PorzionatoDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Carmelo PirriDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Chenglei FanDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Raffaele De CaroDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
Carla SteccoDepartment of Neurosciences, Institute of Human Anatomy, University of Padua, Via A. Gabelli 65, 35121, Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific innervation of the two types of deep fascia, aponeurotic and epymisial fascia. In this work the aponeurotic thoracolumbar fascia and the epymisial gluteal fascia of seven adult C57-BL mice were analysed by Transmission Electron Microscopy and floating immunohistochemistry with the aim to study the organization of nerve fibers, the presence of nerve corpuscles and the amount of autonomic innervation. The antibodies used were Anti-S100, Anti-Tyrosine Hydroxylase and Anti-PGP, specific for the Schwann cells forming myelin, the sympathetic nerve fibers, and the peripheral nerve fibers, respectively. The results showed that the fascial tissue is pervaded by a rhomboid and dense network of nerves. The innervation was statistically significantly lower in the gluteal fascia (2.78 ± 0.6% of positive area, 140.3 ± 31.6/mm

Indexed as

AnimalsAutonomic PathwaysFasciaMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionS100 ProteinsS100 Proteins

Identifiers

PMID34135423
PMCPMC8209020
OpenAlexW3165914326

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.