Evidence map›Paper›PMID 34135368›Full record

ArticleScientific reports2021

Silver nanoparticles produced from Cedecea sp. exhibit antibiofilm activity and remarkable stability.

Priyanka Singh, Santosh Pandit, Carsten Jers, Abhayraj S Joshi, Jørgen Garnæs, Ivan Mijakovic

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Synthesis of Silver Nanoparticles by UsingMolecules (Basel, Switzerland) · 2025
    Article
  11. Lead-free perovskite KCsSnIScientific reports · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Eco-Friendly Synthesis and Characterization ofInternational journal of microbiology · 2025
    Article
  20. Strain-SpecificInternational journal of nanomedicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priyanka SinghThe Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, 2800, Lyngby, Denmark.
Santosh PanditSystems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden.
Carsten JersThe Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, 2800, Lyngby, Denmark.
Abhayraj S JoshiThe Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, 2800, Lyngby, Denmark.
Jørgen GarnæsDanish Fundamental Metrology, Kogle Allé 5, 2970, Hørsholm, Denmark.
Ivan MijakovicThe Novo Nordisk Foundation, Center for Biosustainability, Technical University of Denmark, 2800, Lyngby, Denmark. ivan.mijakovic@chalmers.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With multidrug-resistant bacterial pathogens on the rise, there is a strong research focus on alternative antibacterial treatments that could replace or complement classical antibiotics. Metallic nanoparticles, and in particular silver nanoparticles (AgNPs), have been shown to kill bacterial biofilms effectively, but their chemical synthesis often involves environmentally unfriendly by-products. Recent studies have shown that microbial and plant extracts can be used for the environmentally friendly synthesis of AgNPs. Herein we report a procedure for producing AgNPs using a putative Cedecea sp. strain isolated from soil. The isolated bacterial strain showed a remarkable potential for producing spherical, crystalline and stable AgNPs characterized by UV-visible spectroscopy, transmission electron microscopy, dynamic light scattering, and Fourier transform infrared spectroscopy. The concentration of produced nanoparticles was 1.31 µg/µl with a negative surface charge of - 15.3 mV and nanoparticles size ranging from 10-40 nm. The AgNPs was tested against four pathogenic microorganisms S. epidermidis, S. aureus, E. coli and P. aeruginosa. The nanoparticles exhibited strong minimum inhibitory concentration (MIC) values of 12.5 and 6.25 µg/µl and minimum bactericidal concentration (MBC) values of 12.5 and 12.5 µg/mL against E. coli and P. aeruginosa, respectively. One distinguishing feature of AgNPs produced by Cedecea sp. extracts is their extreme stability. Inductively coupled plasma mass spectrometry and thermogravimetric analysis demonstrated that the produced AgNPs are stable for periods exceeding one year. This means that their strong antibacterial effects, demonstrated against E. coli and P. aeruginosa biofilms, can be expected to persist during extended periods.

Indexed as

Anti-Bacterial AgentsBiofilmsDrug StabilityEnterobacteriaceaeEscherichia coliGreen Chemistry TechnologyMetal NanoparticlesMicrobial Sensitivity TestsParticle SizePseudomonas aeruginosaSilverSoil MicrobiologySpectrophotometry, AtomicStaphylococcus aureusStaphylococcus epidermidisThermogravimetryAnti-Bacterial AgentsSilver

Identifiers

PMID34135368
PMCPMC8209203

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.