Evidence map›Paper›PMID 34135362›Full record

ArticleScientific reports2021

Advanced mycelium materials as potential self-growing biomedical scaffolds.

Maria Elena Antinori, Marco Contardi, Giulia Suarato, Andrea Armirotti, Rosalia Bertorelli, Giorgio Mancini, Doriana Debellis, Athanassia Athanassiou

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Mycobiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria Elena AntinoriSmart Materials, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Marco ContardiSmart Materials, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Giulia SuaratoSmart Materials, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Andrea ArmirottiAnalytical Chemistry Lab, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Rosalia BertorelliTranslational Pharmacology, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Giorgio ManciniSmart Materials, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Doriana DebellisElectron Microscopy Facility, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy.
Athanassia AthanassiouSmart Materials, Fondazione Istituto Italiano Di Tecnologia, Via Morego 30, 16163, Genova, Italy. athanassia.athanassiou@iit.it.
Italian Institute of Technology · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

Indexed as

Cells, CulturedDermisFibroblastsHumansHydrodynamicsMyceliumPleurotusReishiTissue EngineeringTissue Scaffolds

Identifiers

PMID34135362
PMCPMC8209158
OpenAlexW3171440229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.