ArticleNature communications2021
Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 34 citations in OpenAlex.
- Signal extraction in SWAXS data for the compact X-ray light sources: a machine learning approach.Scientific reports · 2026Article
- Single-engineered-residue solvation perturbations regulate global protein architecture and function.Nature communications · 2026Article
- Temporal ghost imaging for pump-probe X-ray solution scattering.Acta crystallographica. Section A, Foundations and advances · 2025Article
- Unveiling hidden wavepacket dynamics in time-resolved x-ray scattering data via singular spectrum analysis.Structural dynamics (Melville, N.Y.) · 2025Article
- Advances in microfluidic mixers for time-resolved structural biology with X-rays.Biophysical reviews · 2025Review
- Ultrafast spectroscopy of liquids using extreme-ultraviolet to soft-X-ray pulses.Nature reviews. Chemistry · 2025Review
- XFEL Beamline Optical Instrumentation for Ultrafast Science.The journal of physical chemistry. B · 2024Review
- A comparative review of time-resolved x-ray and electron scattering to probe structural dynamics.Structural dynamics (Melville, N.Y.) · 2024Review
- Characterization of Biological Samples Using Ultra-Short and Ultra-Bright XFEL Pulses.Advances in experimental medicine and biology · 2024Article
- Cerium Photocatalyst in Action: Structural Dynamics in the Presence of Substrate Visualized via Time-Resolved X-ray Liquidography.Journal of the American Chemical Society · 2023Article
- Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS).Communications biology · 2023Article
- Projection to extract the perpendicular component (PEPC) method for extracting kinetics from time-resolved data.Structural dynamics (Melville, N.Y.) · 2023Article
- Monitoring vibronic coherences and molecular aromaticity in photoexcited cyclooctatetraene with an X-ray probe: a simulation study.Chemical science · 2023Article
- Atomic-scale observation of solvent reorganization influencing photoinduced structural dynamics in a copper complex photosensitizer.Chemical science · 2023Article
- Sample-minimizing co-flow cell for time-resolved pump-probe X-ray solution scattering.Journal of synchrotron radiation · 2023Article
- Effects of ligand binding on dynamics of fatty acid binding protein and interactions with membranes.Biophysical journal · 2022Article
- Serial femtosecond crystallography.Nature reviews. Methods primers · 2022Article
- Reaction dynamics studiedChemical science · 2022Review
- Light-induced protein structural dynamics in bacteriophytochrome revealed by time-resolved x-ray solution scattering.Science advances · 2022Article
- Determining the charge distribution and the direction of bond cleavage with femtosecond anisotropic x-ray liquidography.Nature communications · 2022Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrafast motion of molecules, particularly the coherent motion, has been intensively investigated as a key factor guiding the reaction pathways. Recently, X-ray free-electron lasers (XFELs) have been utilized to elucidate the ultrafast motion of molecules. However, the studies on proteins using XFELs have been typically limited to the crystalline phase, and proteins in solution have rarely been investigated. Here we applied femtosecond time-resolved X-ray solution scattering (fs-TRXSS) and a structure refinement method to visualize the ultrafast motion of a protein. We succeeded in revealing detailed ultrafast structural changes of homodimeric hemoglobin involving the coherent motion. In addition to the motion of the protein itself, the time-dependent change of electron density of the hydration shell was tracked. Besides, the analysis on the fs-TRXSS data of myoglobin allows for observing the effect of the oligomeric state on the ultrafast coherent motion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.