ArticleNature communications2021
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation.Science advances · 2026Article
- Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1.Nature communications · 2026Article
- Metabolite-driven remodeling of hepatic lipid metabolism by the plasticizer di-isononyl phthalate.Molecular metabolism · 2026Article
- Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis.Cell metabolism · 2025Article
- Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction.Cell reports · 2025Article
- Hyperactivation of mTORC1 by an endogenousmicroPublication biology · 2025Article
- The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives.Frontiers in pharmacology · 2025Review
- The Last Universal Common Ancestor of Ribosome-Encoding Organisms: Portrait of LUCA.Journal of molecular evolution · 2024Review
- A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.Nature aging · 2024Article
- Ragopathies and the rising influence of RagGTPases on human diseases.Nature communications · 2024Review
- HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.Science advances · 2024Article
- Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver.Nature communications · 2024Article
- Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division.Nature microbiology · 2024Article
- Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture.Environmental health perspectives · 2023Article
- UPLC-MS based integrated plasma proteomic and metabolomic profiling of TSC-RAML and its relationship with everolimus treatment.Frontiers in molecular biosciences · 2023Article
- Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.Science advances · 2022Article
- The central moTOR of metabolism.Developmental cell · 2022Review
- Protocol for the assessment of mTOR activity in mouse primary hepatocytes.STAR protocols · 2021Article
- Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.Cell reports · 2021Article
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Authors and funding
19 authors at 6 institutions in 4 countries.
Celia de la Calle ArreguiMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-4627-2963
Ana Belén Plata-GómezMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0002-6256-0084
Nerea Deleyto-SeldasMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Fernando GarcíaProteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-3888-4326
Ana Ortega-MolinaMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-2782-8994
Julio Abril-GarridoMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-5732-9016
Elena RodriguezMyocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Ivan NemazanyyPlatform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633, Paris, France.
Laura TribouillardCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, QC, Canada.
Alba de MartinoHistopathology Unit. Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Eduardo CaleirasHistopathology Unit. Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Ramón Campos-OlivasSpectroscopy and NMR Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Francisca MuleroMolecular Imaging Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-9584-4211
Mathieu LaplanteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec, QC, Canada.ORCID 0000-0002-1752-6741
Javier MuñozProteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0003-3288-3496
Mario PendeInstitut Necker Enfants Malades, INSERM U1151, Université de Paris, Paris, France.ORCID 0000-0002-7864-8937
Guadalupe SabioMyocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID 0000-0002-2822-0625
David M SabatiniWhitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, USA.ORCID 0000-0002-1446-7256
Alejo EfeyanMetabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. aefeyan@cnio.es.ORCID 0000-0002-3806-6799
Spanish National Cancer Research Centre · ESInstitut universitaire de cardiologie et de pneumologie de Québec · CASpanish National Centre for Cardiovascular Research · ESBroad Institute · USCentre National de la Recherche Scientifique · FRInserm · FR
Funding
Regulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MCell Growth Signaling in Cancer DevelopmentR01CA129105 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2008 to 2021
$5.9MNovel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8MCIHR 271671CIHR 374552CIHR 419593Howard Hughes Medical InstituteNCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129105NIAID NIH HHS R37 AI047389
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (expression of GTP-locked RagA, or RagA
Indexed as
Signal TransductionAnimalsDisease Models, AnimalFastingGlucoseHomeostasisHumansLiverMechanistic Target of Rapamycin Complex 1MiceMonomeric GTP-Binding ProteinsNutrientsPhenotypePPAR alphaProteomicsSirolimusGlucoseMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsNutrientsPPAR alphaPpara protein, mouseRraga protein, MouseSirolimusTsc1 protein, mouseTuberous Sclerosis Complex 1 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.