Evidence map›Paper›PMID 34135125›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling.

Sara E Konopelski Snavely, Michael W Susman, Ryan C Kunz, Jia Tan, Srisathya Srinivasan, Michael D Cohen, Kyoko Okada, Helen Lamb, Shannon S Choi, Edith P Karuna and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1).Acta crystallographica. Section F, Structural biology communications · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Sara E Konopelski SnavelyDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-7060-3398
Michael W SusmanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Ryan C KunzDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.
Jia TanDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-2079-6937
Srisathya SrinivasanDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-4502-5063
Michael D CohenDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.
Kyoko OkadaDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.
Helen LambDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-4425-7014
Shannon S ChoiDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.
Edith P KarunaDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-7292-9009
Michael K ScalesDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-3645-5643
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115.
Michael Eldon GreenbergDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115; meg@hms.harvard.edu hyhho@ucdavis.edu.ORCID 0000-0003-1380-2160
Hsin-Yi Henry HoDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616; meg@hms.harvard.edu hyhho@ucdavis.edu.
University of California, Davis · USHarvard University · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
New Sample Multiplexing Technologies to Identify Chemical Probes and Illuminate Ubiquitin BiologyR01GM067945 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2003 to 2024
$10.5M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Mechanisms Underlying Neuronal Enhancer Specification During Postnatal CNS DevelopmentR01NS115965 · NINDS · HARVARD MEDICAL SCHOOL · PI GREENBERG, MICHAEL ELDON · 2020 to 2024
$3.2M
Deciphering Wnt-Ror signaling in cytoskeletal regulation and tissue shape controlR35GM119574 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HO, HSIN-YI HENRY · 2016 to 2021
$2.0M
NCI NIH HHS P30 CA093373NICHD NIH HHS P50 HD105351NIGMS NIH HHS R01 GM067945NIGMS NIH HHS R35 GM119574NINDS NIH HHS R01 NS115965
6 · The paper itself

Abstract

Wnt5a-Ror signaling is a conserved pathway that regulates morphogenetic processes during vertebrate development [R. T. Moon

Indexed as

ProteomicsWnt Signaling PathwayAnimalsCell MovementMicePhosphorylationProteasome Endopeptidase ComplexProtein DomainsProteolysisReceptor Tyrosine Kinase-like Orphan ReceptorsReproducibility of ResultsUbiquitinUbiquitin-Protein LigasesWnt-5a ProteinPDZRN3 protein, mouseProteasome Endopeptidase ComplexReceptor Tyrosine Kinase-like Orphan ReceptorsUbiquitinUbiquitin-Protein LigasesWnt-5a ProteinPdzrn3Ror1Ror2Wnt5a

Identifiers

PMID34135125
PMCPMC8237634
OpenAlexW3170116683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.