Evidence map›Paper›PMID 34135098›Full record

ArticleMolecular pharmacology2021

Mice Expressing Regulators of G protein Signaling-insensitive Gαo Define Roles of

Courtney A Bouchet, Kylie B McPherson, Ming-Hua Li, John R Traynor, Susan L Ingram

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Courtney A BouchetDepartment of Neurologic Surgery, Oregon Health & Science University, Portland, Oregon (C.A.B., K.B.M., M.L., S.L.I.); and Department of Pharmacology and Edward F. Domino Research Center, Medical School, Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (J.R.T.).
Kylie B McPhersonDepartment of Neurologic Surgery, Oregon Health & Science University, Portland, Oregon (C.A.B., K.B.M., M.L., S.L.I.); and Department of Pharmacology and Edward F. Domino Research Center, Medical School, Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (J.R.T.).
Ming-Hua LiDepartment of Neurologic Surgery, Oregon Health & Science University, Portland, Oregon (C.A.B., K.B.M., M.L., S.L.I.); and Department of Pharmacology and Edward F. Domino Research Center, Medical School, Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (J.R.T.).
John R TraynorDepartment of Neurologic Surgery, Oregon Health & Science University, Portland, Oregon (C.A.B., K.B.M., M.L., S.L.I.); and Department of Pharmacology and Edward F. Domino Research Center, Medical School, Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (J.R.T.).
Susan L IngramDepartment of Neurologic Surgery, Oregon Health & Science University, Portland, Oregon (C.A.B., K.B.M., M.L., S.L.I.); and Department of Pharmacology and Edward F. Domino Research Center, Medical School, Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (J.R.T.) ingrams@ohsu.edu.
Oregon Health & Science University · USUniversity of Michigan–Ann Arbor · US

Funding

BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Regulator of G protein signaling proteins differentially control opioid analgesiaR01DA035316 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2014 to 2018
$2.7M
Regulation of presynaptic cannabinoid CB1 receptorsF31DA052114 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BOUCHET, COURTNEY ANNE · 2020 to 2021
$92k
NIDA NIH HHS F31 DA052114NIDA NIH HHS R01 DA035316NIDA NIH HHS T32 DA007262
6 · The paper itself

Abstract

Regulators of G protein signaling (RGS) proteins modulate signaling by G protein-coupled receptors. Using a knock-in transgenic mouse model with a mutation in G

Indexed as

Analgesics, OpioidAnimalsBaclofenFemalegamma-Aminobutyric AcidGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha Subunits, Gi-GoInhibitory Postsynaptic PotentialsMaleMiceMice, TransgenicModels, AnimalPresynaptic TerminalsReceptors, GABA-BReceptors, Opioid, muRGS ProteinsAnalgesics, OpioidBaclofengamma-Aminobutyric AcidGnai2 protein, mouseGNAO1 protein, mouseGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha Subunits, Gi-GoReceptors, GABA-BReceptors, Opioid, muRGS Proteins

Identifiers

PMID34135098
PMCPMC8626785
OpenAlexW3167548079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.