Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 5 institutions in 3 countries.
Sigrun R HofmannKlinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0003-3128-1143
Emil CarlssonDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Franz KappluschDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Ana L CarvalhoKlinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Triantafillos LiloglouDepartment of Molecular and Clinical Cancer Medicine, The Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-0460-1404
Felix SchulzeKlinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-8220-5012
Susanne AbrahamKlinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-7457-6481
Sarah NortheyDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-8662-7175
Susanne RussKlinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Anna E A SuraceDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-9589-3005
Nobuya YoshidaDivision of Rheumatology and Clinical Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
George C TsokosDivision of Rheumatology and Clinical Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Christian M HedrichDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom; christian.hedrich@liverpool.ac.uk.ORCID 0000-0002-1295-6179
University of Liverpool · GBKlinik und Poliklinik für Kinder- und Jugendmedizin · DEBeth Israel Deaconess Medical Center · USKlinik und Poliklinik für Psychotherapie und Psychosomatik · DENational Health Service · GB
Funding
Gene transcription in SLER37AI049954 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSOKOS, GEORGE C · 2013 to 2022
$4.8M
NIAID NIH HHS R37 AI049954
6 · The paper itself
Abstract
Effector CD4
Indexed as
AnimalsArthritis, PsoriaticCD4-Positive T-LymphocytesCyclic AMP Response Element ModulatorHumansMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorCyclic AMP Response Element ModulatorPDCD1 protein, humanProgrammed Cell Death 1 Receptor
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4 · full record | OpenQuestion